PMID: 9193922May 1, 1997Paper

Pulmonary structural and extracellular matrix alterations in Fischer 344 rats following subchronic phosgene exposure

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
U P KodavantiG E Hatch

Abstract

Phosgene, an acylating agent, is a very potent inducer of pulmonary edema. Subchronic effects of phosgene in laboratory animals are not well characterized. The purpose of the study was to elucidate potential long-term effects on collagen and elastin metabolism during pulmonary injury/recovery and obtain information about the concentration x time (C x T) behavior of low levels of phosgene. Male Fischer 344 rats (60 days old) were exposed either to clean air or phosgene, 6 hr/day: 0.1 ppm (5 days/week), 0.2 ppm (5 days/week), 0.5 ppm (2 days/week), and 1.0 ppm (1 day/week), for 4 or 12 weeks. A group of rats was allowed clean air recovery for 4 weeks after 12 weeks of phosgene exposure. This exposure scenario was designed to provide equal C x T product for all concentrations at one particular time point except for 0.1 ppm (50% C x T). Phosgene exposure for 4 or 12 weeks increased lung to body weight ratio and lung displacement volume in a concentration-dependent manner. The increase in lung displacement volume was significant even at 0.1 ppm phosgene at 4 weeks. Light microscopic level histopathology examination of lung was conducted at 0.0, 0.1, 0.2, and 1.0 ppm phosgene following 4 and 12 and 16 weeks (recovery). Small but clea...Continue Reading

Citations

Apr 29, 2008·Regulatory Toxicology and Pharmacology : RTP·Jeffrey S GiftBabasaheb Sonawane
Dec 3, 2013·Environmental Pollution·Vibha VermaDes W Connell
Jan 24, 2003·Toxicology and Industrial Health·G HatchD Costa
Nov 13, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wenli LiJuergen Pauluhn
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay Wichers StanekDaniel L Costa
Mar 3, 2001·Journal of Occupational and Environmental Medicine·J Borak, W F Diller
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Todd StedefordChing-Hung Hsu
Oct 16, 2009·Inhalation Toxicology·Dana GlassFemi Adeshina
Apr 11, 2012·Analytical Chemistry·Pradip Kundu, Kuo Chu Hwang

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