Pulmonary support on day of life 30 is a strong predictor of increased 1 and 5-year morbidity in survivors of congenital diaphragmatic hernia

Journal of Pediatric Surgery
Ryan P CauleyJay M Wilson

Abstract

Pulmonary support (PS) on day-of-life-30 (DOL-30) has been shown to be the strongest predictor of subsequent morbidity and in-patient mortality in congenital diaphragmatic hernia (CDH). We hypothesized that PS on DOL-30 can also predict long-term outcomes in CDH survivors. We analyzed records of 201 CDH survivors followed by a single multidisciplinary clinic (1995-2010). Follow-up was 83 and 70% at 1 and 5years respectively. PS was defined as: (1) invasive support (n=44), (2) noninvasive support (n=54), or (3) room air (n=103). Logistic regression was used to estimate the adjusted association of PS on DOL-30 with outcomes at 1 and 5-years. Use of PS on DOL-30 was significantly associated with pulmonary and developmental morbidities at 1 and 5-years. Even after adjusting for defect-size and presence of ventilation/perfusion mismatch, greater PS on DOL-30 was associated with a significantly increased odds of requiring supplemental oxygen and developmental referral at 1-year, and asthma and developmental referral at 5-years. CDH survivors continue to have significant long-term pulmonary and developmental morbidities. PS on DOL-30 is a strong independent predictor of morbidity at 1 and 5-years and may be used as a simple prognostic...Continue Reading

References

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Citations

Mar 5, 2016·Journal of Pediatric Surgery·Sebastian K KingPriscilla P L Chiu
Nov 15, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Minal J PatelUNKNOWN Congenital Diaphragmatic Hernia Study Group
Nov 13, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Makiko FuyukiUNKNOWN Japanese Congenital Diaphragmatic Hernia Study Group
Mar 3, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Ruth B SeabrookUNKNOWN Children’s Hospitals Neonatal Consortium Congenital Diaphragmatic Hernia Focus Group

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