Pulmonary surfactant as vehicle for intratracheally instilled tobramycin in mice infected with Klebsiella pneumoniae

British Journal of Pharmacology
A Van't VeenB Lachmann

Abstract

1. The use of pulmonary surfactant has been proposed as a vehicle for antibiotic delivery to the alveolar compartment of the lung. This study investigated survival rates of mice with a respiratory Klebsiella pneumoniae infection treated intratracheally with tobramycin using a natural exogenous surfactant preparation as vehicle. 2. At day 1 after infection, animals were injected intratracheally with 20 microliters of the following solutions: (1) a mixture of surfactant (500 micrograms) and tobramycin (250 micrograms); (2) tobramycin (250 micrograms) alone; (3) surfactant (500 micrograms) alone; and (4) NaHCO3 buffer (control, sham-treatment). A fifth group received no treatment (control). Deaths were registered every 12 h for 8 consecutive days. 3. The results show an increased survival in the group receiving the surfactant-tobramycin mixture compared to the group receiving tobramycin alone (P < 0.05), the group receiving surfactant alone (P < 0.01) and the control groups (P < 0.01). It is concluded that intratracheal instillation of surfactant-tobramycin is superior to tobramycin alone in protecting animals from death due to a respiratory Klebsiella pneumoniae infection.

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Citations

Apr 20, 2001·Advanced Drug Delivery Reviews·J J HaitsmaB Lachmann
Jan 23, 2003·Medical Engineering & Physics·Yong Liang ZhangRichard V Craster
Apr 16, 1999·British Journal of Pharmacology·A Van't VeenB Lachmann
Sep 20, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Amy L MarcinkowskiTimothy E Corcoran
Mar 8, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Timothy E CorcoranJoseph M Pilewski
Jan 9, 2003·Annual Review of Physiology·James F Lewis, Ruud Veldhuizen
Jun 28, 2005·American Journal of Respiratory and Critical Care Medicine·Hercules TsangarisGeorge Nakos
Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Aug 8, 2015·Clinical Pharmacokinetics·Matthew W LinakisCatherine M T Sherwin
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·G Chimote, R Banerjee
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·G Chimote, R Banerjee
Feb 25, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alberto HidalgoJesús Pérez-Gil
Dec 18, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Alexei A BirkunAnatoly A Snitser
Feb 15, 2014·Biochimica Et Biophysica Acta·Elena Lopez-Rodriguez, Jesús Pérez-Gil
Jul 25, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Alberto HidalgoJesus Perez-Gil
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Nov 28, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alberto HidalgoJesús Pérez-Gil
Feb 6, 2021·Frontiers in Bioengineering and Biotechnology·Cristina García-MoutonJesús Pérez-Gil
Jun 21, 2021·Biochimica Et Biophysica Acta. General Subjects·Martin van EijkHenk P Haagsman
Oct 15, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nicholas D HagesTimothy E Corcoran

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