Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

Journal of Molecular Biology
Juho LiekkinenIlpo Vattulainen

Abstract

Surfactant protein B (SP-B) is essential in transferring surface-active phospholipids from membrane-based surfactant complexes into the alveolar air-liquid interface. This allows maintaining the mechanical stability of the surfactant film under high pressure at the end of expiration, therefore SP-B is crucial in lung function. Despite its necessity, the structure and the mechanism of lipid transfer by SP-B have remained poorly characterized. Earlier, we proposed higher order oligomerization of SP-B into ring-like supramolecular assemblies. In the present work, we used coarse-grained molecular dynamics simulations to elucidate how the ring-like oligomeric structure of SP-B determines its membrane binding and lipid transfer. In particular, we explored how SP-B interacts with specific surfactant lipids, and how consequently SP-B reorganizes its lipid environment to modulate the pulmonary surfactant structure and function. Based on these studies, there are specific lipid-protein interactions leading to perturbation and reorganization of pulmonary surfactant layers. Especially, we found compelling evidence that anionic phospholipids and cholesterol are needed or even crucial in the membrane binding and lipid transfer function of SP-...Continue Reading

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Citations

May 30, 2020·International Journal of Molecular Sciences·Olga CañadasJesús Pérez-Gil
Dec 12, 2020·Frontiers in Cell and Developmental Biology·Juho LiekkinenMatti Javanainen
Nov 27, 2020·Molecular Cell·Navdar SeverTom A Rapoport
Dec 23, 2020·American Journal of Respiratory Cell and Molecular Biology·Julia SchipkeChristian Mühlfeld
Mar 24, 2021·Archives of Biochemistry and Biophysics·José Carlos Castillo-SánchezJesús Pérez-Gil

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