Pulmonary toxicity of e-cigarettes

American Journal of Physiology. Lung Cellular and Molecular Physiology
Lauren F ChunJeffrey E Gotts

Abstract

Electronic cigarettes (e-cigarettes or e-cigs) are designed to heat and aerosolize mixtures of vegetable glycerin, propylene glycol, nicotine, and flavoring additives, thus delivering nicotine by inhalation in the absence of combustion. These devices were originally developed to facilitate smoking cessation and have been available in the United States for over a decade. Since 2010, e-cig use has expanded rapidly, especially among adolescents, despite a paucity of short- and long-term safety data. Patterns of use have shifted to include never smokers and many dual users of e-cigs and combustible tobacco products. Over the last several years, research into the potential toxicities of e-cig aerosols has grown exponentially. In the interim, regulatory policymakers across the world have struggled with how to regulate an increasingly diverse array of suppliers and products, against a backdrop of strong advocacy from users, manufacturers, and tobacco control experts. Herein we provide an updated review of the pulmonary toxicity profile of these devices, summarizing evidence from cell culture, animal models, and human subjects. We highlight the major gaps in our current understanding, emphasize the challenges confronting the scientific...Continue Reading

References

Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M LieberG Todaro
Sep 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L SuberC R Coggins
Jul 10, 2001·Pharmaceutical Research·K J KimE D Crandall
Sep 14, 2001·Occupational and Environmental Medicine·G WieslanderT Lindgren
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kamran AtabaiLorraine B Ware
Aug 2, 2002·The New England Journal of Medicine·Kathleen KreissPaul L Enright
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part a·James M AntoniniJenny R Roberts
Apr 14, 2005·American Journal of Industrial Medicine·Sunil VarugheseSusan M Kennedy
Sep 7, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaohui FangMichael A Matthay
Jul 26, 2006·Inhalation Toxicology·S van EijlN Bloksma
Jan 30, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel L MorganScott M Palmer
Oct 30, 2008·Journal of Immunotoxicology·James M Antonini, Jenny R Roberts
Dec 9, 2008·Chest·Susan Blonshine, Michael D Goldman
Jan 19, 2010·Toxicology·Charles L GaworskiChristopher R E Coggins
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Carolyn S CalfeeMitchell J Cohen
Apr 27, 2012·Lancet·Chi Chiu LeungWeihong Chen
Sep 20, 2012·Reproductive Toxicology·Vasundhra BahlPrue Talbot
Oct 2, 2012·The European Respiratory Journal·Philipp WassmerKatia Boggian
Feb 1, 2013·Inhalation Toxicology·Andreas D FlourisYiannis Koutedakis
Mar 8, 2013·Tobacco Control·Maciej Lukasz GoniewiczNeal Benowitz
Oct 19, 2013·International Journal of Environmental Research and Public Health·Konstantinos E FarsalinosVassilis Voudris
Jan 1, 2014·International Journal of Hygiene and Environmental Health·Wolfgang SchoberHermann Fromme
Feb 12, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Z BeharP Talbot
Apr 16, 2014·Tobacco Control·Tianrong Cheng
Apr 16, 2014·Toxicology and Applied Pharmacology·Sara MariniGiorgio Ficco
May 9, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F CervellatiG Valacchi
May 28, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Barbara DavisPrue Talbot
Jun 4, 2014·Occupational and Environmental Medicine·Kristin J CummingsKathleen Kreiss
Sep 3, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Konstantinos E FarsalinosVassilis Voudris
Sep 4, 2014·The New England Journal of Medicine·Eric R Kandel, Denise B Kandel
Nov 2, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ban A MajeedMichael P Eriksen
Nov 8, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Blair N ColemanBrian A King
Nov 11, 2014·JAMA : the Journal of the American Medical Association·Jessica L Barrington-TrimisRob McConnell
Nov 12, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Suchitra Krishnan-SarinGrace Kong
Dec 3, 2014·Environmental Pollution·Maurizio ManigrassoPasquale Avino

❮ Previous
Next ❯

Citations

Oct 27, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Joseph M Collaco, Sharon A McGrath-Morrow
Feb 14, 2018·Journal of Psychoactive Drugs·Daniel G Orenstein, Stanton A Glantz
Jan 13, 2018·Annual Review of Public Health·Stanton A Glantz, David W Bareham
Feb 3, 2018·The Clinical Respiratory Journal·Mohammad Saud KhanJeffrey Hammersley
Jan 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing LuSharon Rounds
May 10, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Robert UrmanJessica L Barrington-Trimis
Nov 4, 2017·Journal of Applied Physiology·I Mark OlfertPaul D Chantler
Feb 17, 2018·American Journal of Respiratory and Critical Care Medicine·Martin ChaumontPhilippe van de Borne
Mar 9, 2018·American Journal of Respiratory and Critical Care Medicine·Pieter S Hiemstra, Robert Bals
Mar 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E GottsMichael A Matthay
Aug 10, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Constantinos GlynosAndreas Papapetropoulos
Jul 10, 2018·BMJ Case Reports·Darsana ViswamGareth I Walters
Feb 28, 2018·European Journal of Applied Physiology·Toby Mündel, I Mark Olfert
Mar 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E Gotts
Mar 16, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Christian Viniol, Claus F Vogelmeier
Jun 1, 2018·The European Respiratory Journal·Thomas W FerkolUNKNOWN Forum of International Respiratory Societies
Feb 17, 2018·The European Respiratory Journal·Viktorija ReinikovaiteLaima Taraseviciene-Stewart
Mar 2, 2019·Expert Review of Respiratory Medicine·Faraz SiddiquiKamran Siddiqi
Apr 9, 2019·Internal Medicine Journal·Emily Stone, Henry Marshall
Apr 25, 2019·Environmental Health Perspectives·Mi-Sun LeeDavid C Christiani
Jul 18, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karim BahmedBeata Kosmider
Jun 6, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rachael E RaynerEstelle Cormet-Boyaka
Nov 7, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Matthew J Peters
Feb 29, 2020·American Journal of Respiratory Cell and Molecular Biology·MuChun Tsai, Rama K Mallampalli
Apr 23, 2020·The New England Journal of Medicine·Matthew B Stanbrook, Jeffrey M Drazen
Apr 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Claudio Nardiello, Rory E Morty
Jan 17, 2020·Annals of the American Thoracic Society·Mario F Perez, Laura E Crotty Alexander
Sep 22, 2019·Scientific Reports·David G ChapmanCharles G Irvin
May 21, 2020·International Journal of Molecular Sciences·Hussein TraboulsiCarolyn J Baglole
Apr 5, 2020·Journal of General Internal Medicine·Lydia Winnicka, Mangalore Amith Shenoy
Jul 28, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Lin XiaoYuan Jiang
Feb 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Martin ChaumontNadia Debbas
Aug 31, 2019·The European Respiratory Journal·Laimute Taraseviciene-Stewart
Oct 31, 2019·American Journal of Physiology. Cell Physiology·Ross CorridenLaura E Crotty Alexander
Nov 22, 2017·American Journal of Respiratory and Critical Care Medicine·Christopher M EvansDavid A Schwartz
Sep 27, 2019·Inhalation Toxicology·Guanghe WangWeimin Song
Dec 12, 2019·The New England Journal of Medicine·Robert W HallowellLida P Hariri
Aug 23, 2020·International Journal of Molecular Sciences·Brittany N SzafranAlexandra Noël
Sep 29, 2020·Critical Public Health·Julia McQuoidPamela Ling
Nov 18, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rory E Morty
Nov 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Massimo CarusoRiccardo Polosa
Oct 24, 2018·Archives of public health = Archives belges de santé publique·Joshua S Yang, Esther Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
bronchoalveolar lavage
biopsies

Software Mentioned

nCounter

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Amy McQueenWalton Sumner
The Annals of Pharmacotherapy
Katherine Kelly Orr, Nicole J Asal
© 2022 Meta ULC. All rights reserved