Pulmonary Toxoplasmosis Diagnosed on Transbronchial Lung Biopsy in a Mechanically Ventilated Patient

Case Reports in Infectious Diseases
Delyse GargVipul Patel

Abstract

Toxoplasma gondii is a protozoan parasite that infects up to a third of the world's population. Infection is mainly acquired by ingestion of food or water that is contaminated with oocysts shed by cats or consuming undercooked meat containing tissue cysts. Primary infection is subclinical in immunocompetent hosts. Invasive toxoplasmosis often manifests as cerebral toxoplasmosis in immunosuppressed patients. In persons living with human immunodeficiency virus (HIV), toxoplasmosis occurs when CD4 counts are very low and is considered an acquired immunodeficiency syndrome (AIDS) defining illness. Pulmonary toxoplasmosis is rarely seen in the highly active antiretroviral therapy era. The diagnosis can be challenging due to the nonspecific nature of clinical and radiographic findings. In this report, we present a case of pulmonary toxoplasmosis in a new onset AIDS patient, which was initially clinically misdiagnosed as Pneumocystis jiroveci pneumonia (PJP). Due to a poor response to treatment for PJP, the patient underwent a transbronchial lung biopsy, which led to the diagnosis of pulmonary toxoplasmosis.

References

Sep 1, 1992·Radiology·P C Goodman, L M Schnapp
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J Luft, J S Remington
Apr 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C Pomeroy, G A Filice
Mar 1, 1988·The Journal of Infection·R E Holliman
Dec 1, 1987·Critical Care Medicine·P S PincusS Zwi
Feb 1, 1986·Chest·T A PapinJ G Weg
Dec 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C RabaudP Canton
Mar 1, 1997·Critical Care Medicine·J D O'BrienM H Kollef
Mar 29, 2003·The European Respiratory Journal·P A BulpaE J Installé
Jun 15, 2004·Lancet·J G Montoya, O Liesenfeld
May 28, 2005·The Annals of Thoracic Surgery·Ashfaq AhmadAyman O Soubani
Jun 13, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E PetersenB Evengård
Jul 7, 2009·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Fábio Luís Nascimento NoguiDavid Salomão Lewi
Aug 30, 2011·Critical Care : the Official Journal of the Critical Care Forum·Hou-Hsien ChiangChong-Jen Yu
Apr 12, 2012·Clinical Microbiology Reviews·Florence Robert-Gangneux, Marie-Laure Dardé
Jul 27, 2012·Scandinavian Journal of Infectious Diseases·Geita Saadatnia, Majid Golkar
Nov 26, 2014·BMC Pulmonary Medicine·Karina de Souza GiassiRonaldo Adib Kairalla

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Methods Mentioned

BETA
bronchoalveolar
biopsy
bronchoalveolar lavage
PCR

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