Pulmonary toxoplasmosis in patients infected with human immunodeficiency virus: a French National Survey

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
C RabaudP Canton

Abstract

We reviewed all cases of pulmonary toxoplasmosis (PT) that were documented by detection of Toxoplasma gondii in bronchoalveolar lavage fluid specimens during a French nationwide review of extracerebral toxoplasmosis in patients infected with human immunodeficiency virus (HIV). Only 64 cases of proven PT were recorded during the 33-month survey. The patients were similar to other patients with AIDS in terms of age, sex, and risk factors for HIV infection. PT occurred mainly in patients with advanced immunodeficiency (mean [+/- SD] CD4+ lymphocyte count, 40 +/- 75/mm3). Clinical features of PT usually include fever, cough and dyspnea; the associated radiological findings were mainly diffuse interstitial infiltrates. Serological data were uninformative. The treatment for PT was the same as that for cerebral toxoplasmosis. A clinical response was observed for 47% of patients, 23% of whom relapsed. Twenty-four patients (37%) died of toxoplasmosis, and 17 (27%) died of other causes. The median survival time was 150 days. We conclude that PT is an infrequent but severe infection in HIV-patients in France.

Citations

Aug 4, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Laurence Huang, Kristina Crothers
Apr 12, 2012·Clinical Microbiology Reviews·Florence Robert-Gangneux, Marie-Laure Dardé
Mar 8, 2014·Revue des maladies respiratoires·C Mayaud, J Cadranel
May 25, 2013·Clinics in Chest Medicine·Jakrapun Pupaibool, Andrew H Limper
May 25, 2013·Clinics in Chest Medicine·Sofya Tokman, Laurence Huang
Mar 5, 2016·Lung India : Official Organ of Indian Chest Society·Jorge N VelásquezMarcelo Corti
Jan 3, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L B Vaughan, R P Wenzel
Jul 3, 2002·Clinics in Chest Medicine·Alimuddin I Zumla, D Geraint James
Aug 26, 2009·FEMS Immunology and Medical Microbiology·Esaki Muthu ShankarSuniti Solomon
Oct 1, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M DemarB Carme
Dec 3, 2014·Clinics in Chest Medicine·Juan F SanchezAlejandro C Arroliga
Jul 1, 2014·Current Opinion in Infectious Diseases·Kyle R BrownbackSteven Q Simpson
Jul 10, 2001·Parasitology·P Ambroise-Thomas
Mar 10, 2020·Case Reports in Infectious Diseases·Delyse GargVipul Patel

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