Pulmonary tuberculosis in spontaneously diabetic goto kakizaki rats

The Tohoku Journal of Experimental Medicine
Isamu SugawaraSatoru Mizuno

Abstract

As a clinical association is thought to exist between diabetes and tuberculosis, this study was set up to examine whether GK/Jcl diabetic rats are more susceptible to Mycobacterium tuberculosis infection than non-diabetic rats. GK/Jcl diabetic rats were infected aerially with M. tuberculosis and their capacity to control mycobacterial growth, granuloma formation, cytokine secretion by alveolar macrophages and nitric oxide (NO) production was examined. The rats developed large granulomas but not necrotic lesions in their lungs, liver or spleen. This is consistent with a significant increase in number of colony-forming units of M. tuberculosis in the lungs (p<0.01). Expression levels of interferon-gamma, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12 mRNA were lower in GK/Jcl diabetic rats than those in control Wistar rats. Alveolar macrophages from GK/Jcl rats secreted less TNF-alpha and IL-12, and produced less NO compared with those from Wistar rats. No significant difference was observed between phagocytosis of tubercle bacilli by alveolar macrophages from GK/Jcl or Wistar rats. These data show that there is a close association between experimental tuberculosis and diabetes in animals, and that alveolar macrophages...Continue Reading

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Citations

Jan 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hideaki YamasawaYukihiko Sugiyama
Oct 27, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J E StalenhoefR van Crevel
Nov 2, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S W ParkY S Kim
Mar 10, 2007·The Tohoku Journal of Experimental Medicine·Isamu SugawaraSatoru Mizuno
Dec 9, 2008·The Tohoku Journal of Experimental Medicine·Isamu Sugawara, Satoru Mizuno
Oct 24, 2009·The Tohoku Journal of Experimental Medicine·Isamu SugawaraSatoru Mizuno
Oct 7, 2009·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Isamu Sugawara
Oct 4, 2012·Expert Review of Anti-infective Therapy·Christie Y JeonMeghan A Baker
Mar 22, 2006·Cellular Microbiology·Isamu SugawaraSatoru Mizuno
Jan 23, 2014·European Journal of Immunology·Nuria Martinez, Hardy Kornfeld
Oct 27, 2016·PLoS Pathogens·Satyanarayana Swamy CheekatlaRamakrishna Vankayalapati
Jun 16, 2011·The Journal of International Medical Research·Q ZhangI Sugawara
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Therese VallerskogHardy Kornfeld
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Qiyao ChaiCui Hua Liu
Mar 10, 2020·The Journal of Toxicological Sciences·Sosuke KishiYoko Matsuda
Nov 21, 2009·The Lancet Infectious Diseases·Kelly E Dooley, Richard E Chaisson

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