Pulmonary, vascular responses in rats exposed to chronic hypobaric hypoxia at two different altitude levels

Pathology, Research and Practice
K NakanishiC Torikata

Abstract

High altitude hypoxia is known to cause pulmonary hypertension in humans. Altitudes of 5500 m and 4000 m above sea level are considered to be the upper limits for short-term human survival and long-term human residence, respectively. To study the effects of hypobaric-hypoxic environments on pulmonary vascular beds, the physiologic and morphometric differences occurring in the pulmonary arteries of rats at the equivalent of these two altitude levels were compared. One hundred and ninety male rats were housed in a double-roomed mechanical chamber and subjected for 12 weeks to hypobaric-hypoxic environments equivalent to an altitude level of 5500 m or 4000 m. After 6-8 weeks, mean pulmonary arterial pressure (PAPm) was significantly higher in rats at the 5500 m level than in those at 4000 m. The external diameter of muscular arteries (M) and of partially muscular arteries (PM) in the lungs of rats at 8 and 12 weeks, and those of nonmuscular arteries (NM) around the alveolar sacs at 2 and 8 weeks were each significantly less in rats exposed to the 5500 m level than in those at 4000 m. At 4 weeks, the ratio of medial thickness to external diameter for M and PM around the alveolar ducts and alveolar sacs were greater in rats exposed ...Continue Reading

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Citations

Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Jo HasegawaStefan Uhlig
Dec 21, 2006·Respiratory Research·Edouard H DebonneuilEtienne-Emile Baulieu
Mar 8, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichiro OhataToshiaki Kawai
Dec 3, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Catherine M Ivy, Graham R Scott
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Feb 21, 2008·Acta Physiologica·M UenoyamaS Suzuki
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·E A CoppockM M Tamkun

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