PMID: 3760387Nov 1, 1986Paper

Pulmonary vascular supersensitivity to catecholamines in systemic high blood pressure

Journal of the American College of Cardiology
M D GuazziG Tamborini

Abstract

Pulmonary pressure and arteriolar resistance are elevated in uncomplicated primary systemic hypertension. This study was carried out in 16 men with this form of hypertension and in 9 healthy men to compare 1) their pulmonary vascular reactivity to endogenous catecholamines released during mental arithmetic and cold pressor tests, and 2) the dose-response relation to exogenous epinephrine and norepinephrine. Arithmetic and cold pressor tests were associated, respectively, with a predominant increase in plasma epinephrine and norepinephrine concentration; changes were significantly greater in hypertensive men. During the two tests, pulmonary arteriolar resistance in the normotensive group was reduced by 13% and augmented by 7% of baseline, respectively, whereas it was raised by 31 and 70%, respectively, in the hypertensive group. In normal subjects, the dose (microgram)-response (delta dynes) relation to epinephrine was 1 = -4, 2 = -9, 3 = -9 and 4 = -10; to norepinephrine it was 2 = +3, 4 = +6, 6 = +7 and 8 = +7. In hypertensive patients, the respective relations were 1 = +18, 2 = +44, 3 = +59 and 4 = +77; and 2 = +39, 4 = +54, 6 = +76 and 8 = +98. Group differences were highly significant. In each of these circumstances, the dr...Continue Reading

References

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Citations

Jan 23, 2016·Journal of the American College of Cardiology·Gregory D LewisRobert E Gerszten
Oct 15, 1990·The American Journal of Cardiology·C M CipollaM D Guazzi
Jun 15, 2013·Blood Pressure·Cesare CuspidiGianfranco Parati
Jun 22, 2001·The American Journal of the Medical Sciences·G MarenziP Agostoni
Feb 1, 1989·Circulation·M D GuazziG Tamborini
Jul 2, 2014·Journal of Cardiovascular Medicine·Marijana Tadic, Branislava Ivanovic
Mar 2, 2013·Journal of Hypertension·Cesare CuspidiUNKNOWN Working Group on Heart, Hypertension of the Italian Society of Hypertension

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