PMID: 2507232Oct 1, 1989Paper

Pulmonary vasodilation with prostacyclin in primary and secondary pulmonary hypertension

Chest
K JonesJ Wallwork

Abstract

Twenty-three patients with pulmonary hypertension underwent right cardiac catheterization and measurement of their response to a short-term infusion of prostacyclin. Pulmonary vasodilation with a greater than 20 percent fall in PVR occurred in all five patients with primary pulmonary hypertension where the predominant lesions were plexogenic; in three out of five patients where the predominant lesions were thrombotic; in three out of five patients with pulmonary hypertension and obstruction of proximal vessels; in three out of five patients with COPD; in both patients with pulmonary fibrosis due to sarcoidosis; and in the one patient with pulmonary veno-occlusive disease, where the pulmonary vasodilation was offset by a fall in arterial oxygen content. Prostacyclin is a safe and effective drug to use for testing the response of the pulmonary circulation to a vasodilator in pulmonary hypertension due to different causes. Short-term testing for a vasodilator response, with a view to instituting long-term therapy, should not be restricted to those patients with primary pulmonary hypertension due to plexogenic pulmonary arteriopathy.

References

Oct 1, 1979·The Journal of Clinical Investigation·D R Dantzker, J S Bower
Nov 1, 1977·Circulation·W D Edwards, J E Edwards
Sep 1, 1987·British Heart Journal·D HeathP Harris
Jan 1, 1985·British Heart Journal·C M Oakley
May 5, 1983·The New England Journal of Medicine·E H Bergofsky
Sep 1, 1980·British Heart Journal·J SzczeklikR Nizankowski
Mar 1, 1982·Clinical Science·J M Richens, P Howard

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Citations

Dec 1, 1996·Clinical Cardiology·A Blum, D Aravot
Jan 19, 1995·The American Journal of Cardiology·N GalièB Magnani
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tamera J CorteStephen J Wort
Apr 1, 1992·British Journal of Industrial Medicine·Z DujićD Eterović
Nov 19, 2005·Respiration; International Review of Thoracic Diseases·Raymond J Foley, Mark L Metersky
Oct 26, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·K OlmstedT Raghuveer
Mar 26, 1998·Journal of Cardiovascular Pharmacology·A SaadjianS Levy
Nov 26, 2013·Clinics in Chest Medicine·Tim Lahm, Murali M Chakinala
Dec 26, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jørn CarlsenClaus Bøgelund Andersen
Sep 27, 2012·Progress in Cardiovascular Diseases·Hooman D PoorSean M Studer
Sep 14, 2001·Chest·L S Efferen
Mar 14, 2007·Mayo Clinic Proceedings·Jay H RyuMichael D McGoon
Jun 10, 2008·Clinics in Chest Medicine·Enrique Diaz-GuzmanDaniel A Culver
May 1, 1990·Respiratory Medicine·A T Dinh XuanJ Wallwork
Nov 1, 1990·Respiratory Medicine·P J ChapmanS R Benatar
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·A S BaconJ I McGill
Oct 21, 2005·Chest·Charlie Strange
Feb 7, 2002·Expert Opinion on Pharmacotherapy·Vallerie V McLaughlin
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Dec 21, 2019·BMC Pulmonary Medicine·Qin LuoZhihong Liu

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