PMID: 6407362Jun 1, 1983Paper

Pulmonary vasodilator effects of nitroglycerin and sodium nitroprusside in canine oleic acid-induced pulmonary hypertension

Anesthesiology
R G PearlJ P Ashton

Abstract

The hemodynamic effects of nitroglycerin (TNG) and sodium nitroprusside (SNP) were studied in a canine model of pulmonary hypertension. Oleic acid administration resulted in pulmonary hypertension with a 133% increase in pulmonary vascular resistance (PVR), a 40% increase in mean pulmonary artery pressure (MPAP), and a 28% decrease in cardiac output (CO). In this model, subsequent TNG administration increased CO 40%, decreased PVR 43%, and decreased MPAP 12%; pulmonary hemodynamics during TNG administration were not significantly different from those prior to oleic acid administration. SNP produced systemic hypotension but did not alter either PVR or MPAP and increased CO only 14%. The efficacy of TNG in this model may relate to its ability to dilate preferentially the pulmonary vascular bed.

Citations

Mar 16, 2007·Biomechanics and Modeling in Mechanobiology·Keshava RajagopalK R Rajagopal
Dec 1, 1992·Journal of Pharmacological and Toxicological Methods·H TanakaK Kobayashi
Nov 1, 1995·Critical Care Medicine·I Matot, C F Neely
Jul 20, 2002·Critical Care Medicine·Sophia Abdel KafiRobert Naeije
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Jun 14, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B B Lee

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