PMID: 8967512May 1, 1996Paper

Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats

The American Journal of Physiology
B D NossamanP J Kadowitz

Abstract

Responses to and the mechanism of action of adrenomedullin (ADM), the carboxy-terminal fragments of ADM, and calcitonin gene-related peptide (CGRP), a structurally related peptide, were investigated in the pulmonary vascular bed of the rat. Under conditions of elevated tone and controlled pulmonary blood flow in the isolated blood-perfused rat lung, injections of ADM, the 15-52 amino acid carboxy-terminal ADM analogue (ADM15-52), and CGRP caused dose-related decreases in pulmonary arterial perfusion pressure. In contrast, the carboxy-terminal 22-52 and 40-52 amino acid fragments had no consistent vasodilator activity. After administration of the nitric oxide synthase inhibitors, N omega-nitro-L-arginine benzyl ester or N omega-nitro-L-arginine methyl ester (L-NAME), pulmonary vasodilator responses to ADM, to ADM15-52, to CGRP, to acetylcholine, and to bradykinin were significantly decreased in the rat, whereas vasodilator responses to isoproterenol and nitroglycerin were not changed. However, in the pulmonary vascular bed of the cat, L-NAME had no significant effect on vasodilator responses to ADM in doses that attenuated vasodilator responses to acetylcholine and bradykinin. L-NAME had no effect on responses to isoproterenol o...Continue Reading

Citations

Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y TakahashiM A Heymann
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P KinnunenI Szokodi
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hunter C ChampionPhilip J Kadowitz
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K TerataD D Gutterman
Mar 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Charles E Norton, Steven S Segal
Oct 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Noritoshi NagayaKenji Kangawa
Mar 29, 2002·Microscopy Research and Technique·Kazuo KitamuraTanenao Eto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.