Pulmonary vein isolation using a compliant endoscopic laser balloon ablation system in a swine model.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Edward P Gerstenfeld, J J Michele

Abstract

The incidence of pulmonary vein reconnection and recurrent atrial fibrillation after a single catheter ablation procedure is unacceptably high. We studied the ability of a novel endoscopic laser balloon ablation system (EAS) to achieve acute and chronic pulmonary vein (PV) isolation in a swine model. Eight swine underwent EAS ablation and two underwent standard radiofrequency ablation for comparison. In the EAS arm, laser energy was delivered under visual guidance around the PV antrum in overlapping 30-degree arcs. In the standard ablation arm, radiofrequency energy was delivered via a 4-mm-tip catheter. PV isolation was confirmed acutely after 30 min, and reassessed after 4-6 weeks. Animals were then sacrificed for histopathologic analysis of the PVs. For the EAS animals, 44 ± 10 overlapping lesions were required to achieve acute RSPV isolation. Chronic PV isolation was documented with the circular mapping catheter a mean of 28 ± 9 days after ablation in 7/8 animals (83%). In the standard ablation arm, 30 ± 3 RF lesions were delivered to achieve acute PV isolation. There was evidence of PV reconnection in both animals during the chronic study. Histologically, completely transmural circumferential lesions were found in 7/8 EAS ...Continue Reading

References

May 14, 2003·Journal of Cardiovascular Electrophysiology·Francis E MarchlinskiErica Zado
Sep 15, 2004·Journal of Cardiovascular Electrophysiology·Thomas ArentzMichel Haissaguerre
Sep 15, 2004·Journal of Cardiovascular Electrophysiology·David J CallansFrancis E Marchlinski
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kristina LemolaHakan Oral
Oct 5, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Aamir CheemaHugh Calkins
Nov 4, 2006·Journal of Cardiovascular Electrophysiology·Sumeet K MainigiFrancis E Marchlinski
Mar 31, 2007·Journal of Cardiovascular Electrophysiology·Aamir CheemaHugh Calkins

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Citations

Nov 7, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stefano BordignonBoris Schmidt
Aug 10, 2012·PloS One·Peter LeeChristopher E Woods
Feb 2, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Srinivas R DukkipatiVivek Y Reddy
May 27, 2016·Pacing and Clinical Electrophysiology : PACE·Tim VandecasteeleGlenn VAN Langenhove
Mar 14, 2013·Expert Review of Medical Devices·Stefano BordignonBoris Schmidt

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