Pulmonary venous structural remodeling in a canine model of chronic atrial dilation due to mitral regurgitation.

The Canadian Journal of Cardiology
Qi SunShu Zhang

Abstract

Structural remodelling plays an important role in the genesis and maintenance of atrial fibrillation (AF). Although some studies that associate structural remodelling with atrial dilation have been reported, structural pulmonary venous (PV) remodelling due to chronic atrial dilation remains unclear. Six sham dogs and five mitral regurgitation (MR) dogs (three months after partial mitral valve avulsion) were studied. Separate cryosections from the PV and left atrium (LA) were immunolabelled with antibodies against connexin (Cx) 40 and Cx43 and analyzed by confocal laser scanning microscopy. Tissue samples from the PV and LA were stained with hematoxylin and eosin, and Masson's trichrome. In MR models, a decrease in Cx40 (0.57+/-0.2% versus 1.18+/-0.3%, P<0.05) and Cx43 (0.48+/-0.2% versus 1.56+/-0.5%, P<0.05) expression was observed compared with sham dogs. The distribution pattern of Cx40 and Cx43 changed from homogeneous to heterogeneous. Gap junction remodelling was not observed in the LA. In Masson's trichrome-stained sections from MR dogs, regions with increased interstitial fibrosis were present in the PV. Thickness in the PV and the PV-LA junction did not change in the MR group. The present study demonstrated a decrease i...Continue Reading

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Citations

Mar 27, 2009·Anatomical Science International·Tetsuichiro Inai, Yosaburo Shibata
Jun 19, 2009·Cardiovascular Research·Sevasti-Maria ChaldoupiHarold V M van Rijen
May 26, 2018·Experimental Animals·Bo LiYue Tang
Jul 28, 2020·Circulation Research·Dominik SchüttlerWilliam J Hucker
Jan 2, 2020·International Journal of Molecular Sciences·Said MasoudKatja Rietdorf
Jan 27, 2019·Journal of the American College of Cardiology·Michael A BorgerRobert A Levine

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