Abstract
The ability of several vasodilators to inhibit the responses to noradrenaline and U46619 (a thromboxane A2 analog) in isolated pulmonary and mesenteric arteries of neonatal piglets was compared. In pulmonary arteries, acetylcholine produced endothelium-dependent relaxations (pIC50 = about 6.8) while, in mesenteric arteries, a relaxant (< or = 10(-7) M) or a contractile response (> or = 10(-6) M) was observed. Sodium nitroprusside produced relaxant effects in pulmonary and mesenteric arteries contracted by noradrenaline (pIC50 = 6.6 and 6.0, respectively) and U46619 (pIC50 = 5.4 and 6.7, respectively). ATP induced an endothelium-independent relaxation in pulmonary arteries (pIC50 = about 4) but in mesenteric arteries it produced weak relaxant effects. In resting mesenteric arteries, ATP induced a concentration-dependent contraction which was not observed in pulmonary arteries. Prostaglandin E1 induced a contractile effect whereas, at higher concentrations, a relaxant response was observed. The alpha-adrenoceptor antagonist tolazoline had no effect on arteries contracted by U46619 but relaxed arteries contracted by noradrenaline being slightly more potent in mesenteric than in pulmonary arteries (pIC50 = 5.1 and 4.8, respectively...Continue Reading
References
Oct 1, 1979·The Journal of Pediatrics·D K StevensonP Sunshine
Oct 3, 1992·Lancet·J D RobertsW M Zapol
Oct 3, 1992·Lancet·J P KinsellaS H Abman
Jan 1, 1992·Archives of Disease in Childhood·Y K Abu-OsbaA Rejjal
Jul 1, 1991·The Journal of Pediatrics·G G Konduri, L L Woodard
Nov 1, 1989·British Journal of Pharmacology·S F LiuP J Barnes
Jan 1, 1985·The Journal of Pediatrics·W E BenitzP Sunshine
Nov 27, 1980·Nature·R F Furchgott, J V Zawadzki
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·C CauvinC Van Breemen
Dec 1, 1984·Pediatric Research·P J DicksteinE Bancalari
Nov 1, 1981·Prostaglandins and Medicine·M B StarlingR B Elliott
Dec 1, 1980·Pediatric Research·M E TrippA M Rudolph
Jun 25, 1981·The New England Journal of Medicine·G SimonneauA Lockhart
Aug 1, 1995·Pediatric Research·G ZobelI Friehs
May 1, 1995·British Journal of Pharmacology·E VillamorJ Tamargo
Jan 1, 1995·Annual Review of Physiology·J R FinemanM A Heymann
Oct 1, 1994·British Journal of Pharmacology·Y M QianJ K Ho
Jan 1, 1995·British Heart Journal·J C WelchJ L Gibbs
Dec 1, 1994·British Journal of Pharmacology·F Pérez-VizcaínoJ Tamargo
Sep 1, 1994·Circulation·M M BrookS J Soifer
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·E L DobynsK R Stenmark
May 1, 1996·Journal of Vascular Research·F Pérez-VizcaínoJ Tamargo
Citations
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·M Glavind-KristensenV E Hjortdal
Apr 16, 1998·British Journal of Pharmacology·F Pérez-VizcaínoJ Tamargo
Oct 12, 1999·British Journal of Pharmacology·M R McMillanS G Haworth
Feb 22, 2001·British Journal of Pharmacology·A L CogolludoJ Tamargo
Jan 27, 2021·Antioxidants·Daniel Morales-CanoFrancisco Perez-Vizcaino