Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review

Journal of Endodontics
Marjorie ZaniniStéphane Simon

Abstract

Similar to other tissues, the dental pulp mounts an inflammatory reaction as a way to eliminate pathogens and stimulate repair. Pulp inflammation is prerequisite for dentin pulp complex repair and regeneration; otherwise, chronic disease or pulp necrosis occurs. Evaluation of pulp inflammation severity is necessary to predict the clinical success of maintaining pulp vitality. Clinical limitations to evaluating in situ inflammatory status are well-described. A molecular approach that aids clinical distinction between reversible and irreversible pulpitis could improve the success rate of vital pulp therapy. The aim of this article is to review inflammatory mediator expression in the context of clinical diagnosis. We searched PubMed and Cochrane databases for articles published between 1970 and December 2016. Only published studies of inflammatory mediator expression related to clinical diagnosis were eligible for inclusion and analysis. Thirty-two articles were analyzed. Two molecular approaches were described by study methods, protein expression analysis and gene expression analysis. Our review indicates that interleukin-8, matrix metalloproteinase 9, tumor necrosis factor-α, and receptor for advanced glycation end products expr...Continue Reading

Citations

Apr 18, 2019·The Journal of International Medical Research·Mengjie LiDongmei Deng
Apr 16, 2019·International Endodontic Journal·L BjørndalH F Duncan
Sep 19, 2019·Brazilian Oral Research·Brenda Eréndida Castillo-SilvaNuria Patiño-Marín
Jun 5, 2020·International Endodontic Journal·C BrizuelaV Ramírez
Jun 20, 2020·Brazilian Dental Journal·Cláudio Antonio Talge CarvalhoLuciane Dias de Oliveira
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Elodie MaisonneuveHalima Kerdjoudj
Jul 5, 2019·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·J EvangelinVijay Velu
Dec 23, 2020·Medicine·Eva Concepción Aguirre-LópezPedro Rosales-García
Apr 6, 2021·Australian Dental Journal·D Yong, P Cathro
May 9, 2021·International Endodontic Journal·Banan Al-NatourIkhlas A El-Karim
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Konstantina KritikouTudor Spinu
Aug 6, 2021·Journal of Endodontics
Aug 11, 2021·International Endodontic Journal·José Luis Muñoz-CarrilloOscar Gutiérrez-Coronado
Aug 28, 2021·Cells·José Luis Muñoz-CarrilloKarla Karina Díaz-Huerta

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