PMID: 8950655Nov 1, 1996Paper

Pulsatile albumin transport in large arteries: a numerical simulation study

Journal of Biomechanical Engineering
G Rappitsch, K Perktold

Abstract

Albumin transport in a stenosed artery configuration is analyzed numerically under steady and pulsatile flow conditions. The flow dynamics is described applying the incompressible Navier-Stokes equations for Newtonian fluids, the mass transport is modelled using the convection diffusion equation. The boundary conditions describing the solute wall flux take into account the concept of endothelial resistance to albumin flux by means of a shear dependent permeability model based on experimental data. The study concentrates on the influence of steady and pulsatile flow patterns and of regional variations in vascular geometry on the solute wall flux and on the ratio of endothelial resistance to concentration boundary layer resistance. The numerical solution of the Navier-Stokes equations and of the transport equation applies the finite element method where stability of the convection dominated transport process is achieved by using an upwind procedure and a special subelement technique. Numerical simulations are carried out for albumin transport in a stenosed artery segment with 75 percent area reduction representing a late stage in the progression of an atherosclerotic disease. It is shown that albumin wall flux varies significantl...Continue Reading

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Citations

Jan 4, 2006·Annals of Biomedical Engineering·David A Steinman, Charles A Taylor
Jul 17, 2007·Annals of Biomedical Engineering·Nanfeng SunX Yun Xu
Aug 21, 2002·Computer Methods in Biomechanics and Biomedical Engineering·D Kim Stangeby, C Ross Ethier
Feb 2, 2011·Journal of Biomechanical Engineering·G T CarrollM T Walsh
Dec 17, 2009·Annals of Biomedical Engineering·Yohsuke ImaiTakami Yamaguchi
Sep 5, 2007·Clinical Biomechanics·Jinxing HongWenchang Tan
Jun 18, 2004·Annals of the New York Academy of Sciences·Shmuel Einav, Danny Bluestein
May 4, 2004·Magnetic Resonance Imaging·Liang-Der JouD Saloner
Nov 21, 2007·Clinical Biomechanics·Aike Qiao, Youjun Liu
May 20, 2003·Journal of Biomechanical Engineering·Elizabeth M LutostanskyKarl Perktold
Mar 2, 2002·Journal of Biomechanical Engineering·D Kim Stangeby, C Ross Ethier
Mar 31, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Baptiste MichelAntonino Nicoletti
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nanfeng SunX Yun Xu
Sep 13, 2005·Computer Methods in Biomechanics and Biomedical Engineering·Jaroslav Mackerle
Aug 9, 2019·Bulletin of Mathematical Biology·Moritz P ThonMichael W Gee
Nov 25, 2019·Computers in Biology and Medicine·Ashish SaxenaEddie Yin Kwee Ng

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