PMID: 16532621Mar 15, 2006Paper

Pulsatile flow and mass transport over an array of cylinders: gas transfer in a cardiac-driven artificial lung

Journal of Biomechanical Engineering
Kit Yan ChanJames B Grotberg

Abstract

The pulsatile flow and gas transport of a Newtonian passive fluid across an array of cylindrical microfibers are numerically investigated. It is related to an implantable, artificial lung where the blood flow is driven by the right heart. The fibers are modeled as either squared or staggered arrays. The pulsatile flow inputs considered in this study are a steady flow with a sinusoidal perturbation and a cardiac flow. The aims of this study are twofold: identifying favorable array geometry/spacing and system conditions that enhance gas transport; and providing pressure drop data that indicate the degree of flow resistance or the demand on the right heart in driving the flow through the fiber bundle. The results show that pulsatile flow improves the gas transfer to the fluid compared to steady flow. The degree of enhancement is found to be significant when the oscillation frequency is large, when the void fraction of the fiber bundle is decreased, and when the Reynolds number is increased; the use of a cardiac flow input can also improve gas transfer. In terms of array geometry, the staggered array gives both a better gas transfer per fiber (for relatively large void fraction) and a smaller pressure drop (for all cases). For most...Continue Reading

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Citations

Apr 6, 2007·Journal of Biomechanical Engineering·Jennifer R ZierenbergJames B Grotberg
Sep 25, 2007·Journal of Biomechanical Engineering·Kit Yan ChanJames B Grotberg
Jun 6, 2008·Journal of Biomechanical Engineering·Jennifer R ZierenbergJames B Grotberg
May 18, 2011·Physics of Fluids·Adnan QamarJoseph L Bull
Jun 28, 2011·International Journal of Heat and Mass Transfer·Yu-Chun LinJoseph L Bull
Aug 31, 2010·Journal of Membrane Science·M Ertan TaskinZhongjun J Wu
Jun 29, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Adnan Qamar, Joseph L Bull
Dec 23, 2016·Journal of Biomechanical Engineering·Kenny W Q LowJohann Sienz
Oct 22, 2013·Journal of Biomechanical Engineering·Jiafeng ZhangZhongjun J Wu
Dec 14, 2011·Bioinspiration & Biomimetics·R SchuechM A R Koehl
Dec 4, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andreas KaeslerJutta Arens
Jul 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Cameron C JonesJoseph B Zwischenberger
Jul 12, 2021·Computer Methods and Programs in Biomedicine·Tao-Qian TangKuang C Lin

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