Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study

Fluids and Barriers of the CNS
Julian Rey, Malisa Sarntinoranont

Abstract

In animal models, dissolved compounds in the subarachnoid space and parenchyma have been found to preferentially transport through the cortex perivascular spaces (PVS) but the transport phenomena involved are unclear. In this study two hydraulic network models were used to predict fluid motion produced by blood vessel pulsations and estimate the contribution made to solute transport in PVS and parenchyma. The effect of varying pulse amplitude and timing, PVS dimensions, and tissue hydraulic conductivity on fluid motion was investigated. Periodic vessel pulses resulted in oscillatory fluid motion in PVS and parenchyma but no net flow over time. For baseline parameters, PVS and parenchyma peak fluid velocity was on the order of 10 μm/s and 1 nm/s, with corresponding Peclet numbers below 103 and 10-1 respectively. Peak fluid velocity in the PVS and parenchyma tended to increase with increasing pulse amplitude and vessel size, and exhibited asymptotic relationships with hydraulic conductivity. Solute transport in parenchyma was predicted to be diffusion dominated, with a negligible contribution from convection. In the PVS, dispersion due to oscillating flow likely plays a significant role in PVS rapid transport observed in previous...Continue Reading

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Citations

Oct 24, 2019·Journal of the Royal Society, Interface·John H Thomas
Jun 21, 2019·Fluids and Barriers of the CNS·Jeffrey TithofJohn H Thomas
Oct 21, 2018·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand
Aug 9, 2019·Scientific Reports·Kulam Najmudeen MagdoomMalisa Sarntinoranont
Apr 18, 2020·Fluids and Barriers of the CNS·Vegard VinjeKaren-Helene Støverud
Nov 14, 2019·Biomechanics and Modeling in Mechanobiology·Adam D Martinac, Lynne E Bilston
Feb 6, 2020·Fluids and Barriers of the CNS·Hazel C JonesLester R Drewes
Feb 6, 2019·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Nov 11, 2020·Journal of the Royal Society, Interface·Fatima Min RivasDouglas H Kelley
Dec 30, 2020·PloS One·Cécile Daversin-CattyMarie E Rognes
Dec 5, 2020·Scientific Reports·Francesco RomanòJames B Grotberg
Feb 7, 2021·Journal of Biomechanics·Mohammad M Faghih, M Keith Sharp
May 25, 2021·Frontiers in Psychiatry·Tao YanLinglin Yang
Aug 11, 2021·Scientific Reports·Vegard VinjeMarie E Rognes
Jan 27, 2022·Journal of the Royal Society, Interface·Helena E SchrederKimberly A S Boster

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MATLAB

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