Pulsatile growth hormone secretion in patients with acromegaly and normal men: the effects of growth hormone-releasing hormone infusion

The Journal of Clinical Endocrinology and Metabolism
M C GelatoG R Merriam

Abstract

Twenty-four GH secretory patterns were studied before and during continuous infusions of GHRH in six patients with active acromegaly and in six normal adult men. GH release was episodic in both groups. Control subjects showed a normal diurnal variation in GH release, with the majority of GH released at night (2200-0800 h); mean levels were 1.5 +/- 0.4 (SE) ng/mL (day) and 4.2 +/- 0.8 ng/mL (night). Acromegalics had no diurnal variation in GH; levels were 45.3 +/- 13.7 ng/mL (day) and 39.8 +/- 12.2 ng/mL (night). Acromegalics demonstrated an increased frequency of GH pulses compared to normals (11.8 +/- 0.8 vs. 2.2 +/- 0.3/24 h). During continuous 24-h infusions of GHRH, the normal subjects continued to show a diurnal variation in GH release, but GH pulse frequency increased to a rate (11.7 +/- 1.4 pulses/24 h) very similar to that of the patients with acromegaly. In contrast, GHRH infusion did not alter the GH pulse frequency in the acromegalics. GHRH increased the mean levels of GH in both groups (patients 80.2 +/- 20.3 vs. 41.0 +/- 12.1 ng/mL, x +/- SE. P less than 0.05; controls 10.2 +/- 2.0 vs. 3.33 +/- 0.5 ng/mL, P less than 0.01). Some of the patients with acromegaly showed a progressive decline in GH levels during the in...Continue Reading

Citations

Sep 1, 1992·Clinical Endocrinology·M RiedelG Brabant
Sep 22, 2007·Advanced Drug Delivery Reviews·Michael H Smolensky, Nicholas A Peppas
May 6, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jose Cordoba-ChaconRhonda D Kineman
Sep 1, 1999·Clinical Endocrinology·S Chappel
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·A M CotterillM O Savage
Sep 25, 2003·American Journal of Physiology. Endocrinology and Metabolism·Nienke R BiermaszFerdinand Roelfsema
Jul 1, 1993·The Journal of Pediatric Endocrinology·A LiuzziP G Chiodini

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