PMID: 1911139Jul 1, 1991Paper

Pulsatile immunoreactive and bioactive luteinizing hormone secretion in adolescents with chronic renal failure. The Cooperative Study Group on Pubertal Development in Chronic Renal Failure (CSPCRF)

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
F SchaeferW R Robertson


Delayed or arrested pubertal development is common in children with chronic renal failure (CRF). Normal puberty is initiated by the onset of episodic nocturnal secretion of luteinizing hormone (LH) containing an increasing proportion of bioactive hormone. To test the functional integrity of the hypothalamo-pituitary axis in CRF we measured immunoreactive (i-LH) and bioactive (bio-LH) plasma LH concentrations at 15-min intervals from 2000 to 0700 hours in 65 pubertal patients aged 10-23 years [46 boys/19 girls; 20 on conservative treatment (CT), 13 on dialysis (D), 32 with transplants (TP)]. i-LH was determined by radio-immunoassay and bio-LH by a mouse Leydig cell assay. Peak detection was performed by the cluster analysis computer programme. The mean (+/- SD) number of i-LH (in both sexes) and bio-LH pulses (in boys) per profile, and the mean peak area of i-LH (in both sexes) and bio-LH (in girls) were higher in TP than in CT or D patients. The ratio of bio-LH to i-LH increased during puberty in CT (G1 vs G4/5, 0.3 +/- 0.5 vs 1.8 +/- 0.,4) and TP (0.6 +/- 0.7 vs 1.8 +/- 0.7) but remained low in male D patients (0.4 +/- 0.7 vs 1.1 +/- 0.8). The ratios were subnormal, however, even in mature TP patients compared with healthy adu...Continue Reading


Jun 2, 1977·The New England Journal of Medicine·S HoldsworthD M de Kretser
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R PennyS D Frasier
Oct 1, 1976·The Journal of Clinical Investigation·K MartinE Slatopolsky
May 1, 1990·Acta Endocrinologica·J A TalbotW R Robertson
Mar 1, 1986·The American Journal of Physiology·K G MandelK Dharmsathaphorn
Jan 1, 1989·Acta Endocrinologica·F SchaeferK Schärer
Jun 1, 1987·The Journal of Endocrinology·A LambertW R Robertson
Dec 1, 1987·Clinical Endocrinology·A TsatsoulisW R Robertson
Aug 1, 1987·Clinical Endocrinology·W R RobertsonN Loveridge
Jun 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J D Veldhuis, M L Johnson
Mar 1, 1987·The Journal of Pediatrics·R van Diemen-SteenvoordeM C de Jong
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Feb 1, 1981·Pediatric Research·K P CorleyJ C Marshall
Jul 1, 1982·The Journal of Clinical Endocrinology and Metabolism·B H RichV Fang

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Jul 29, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter Haffner, Miroslav Zivicnjak
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