Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes

Diabetes
Jian-Man LinP Bergsten

Abstract

Plasma insulin in healthy subjects shows regular oscillations, which are important for the hypoglycemic action of the hormone. In individuals with type 2 diabetes, these regular variations are altered, which has been implicated in the development of insulin resistance and hyperglycemia. The origin of the change is unknown, but derangement of the islet secretory pattern has been suggested as a contributing cause. In the present study, we show the dynamics of insulin release from individually perifused islets isolated from three subjects with type 2 diabetes. Insulin release at 3 mmol/l glucose was 10.5 +/- 4.5 pmol.g(-1).s(-1) and pulsatile (0.26 +/- 0.05 min(-1)). In islets from one subject, 11 mmol/l glucose transiently increased insulin release by augmentation of the insulin pulses without affecting the frequency. Addition of 1 mmol/l tolbutamide did not increase insulin release. In islets from the remaining subjects, insulin release was not affected by 11 mmol/l glucose. Tolbutamide transiently increased insulin release in islets from one subject. Insulin release from four normal subjects at 3 mmol/l glucose was 4.3 +/- 0.8 pmol.g(-1).s(-1) and pulsatile (0.23 +/- 0.03 min(-1)). At 11 mmol/l glucose, insulin release increase...Continue Reading

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Citations

Jan 19, 2008·Diabetes, Obesity & Metabolism·R LupiP Marchetti
Mar 15, 2006·Medicine and Science in Sports and Exercise·Adam L MacDonaldPeter W Watt
Sep 26, 2015·Biomedical Reports·Mahmoud HashemitabarFreshteh Nejaddehbashi
May 19, 2009·Medical Hypotheses·M Reza MirbolookiJonathan R T Lakey
Dec 10, 2008·Molecular and Cellular Endocrinology·V MarigoH Cheng
Sep 25, 2007·Regulatory Peptides·Piero MarchettiFrancesco Purrello
Jun 30, 2006·Cell Calcium·Henrique ChengReinhold Penner
Mar 15, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Piero MarchettiSilvia Del Guerra
Jun 22, 2005·Journal of Theoretical Biology·A St Clair GibsonE V Lambert
Feb 1, 2015·Molecular Aspects of Medicine·Leslie S SatinArthur S Sherman
Feb 12, 2009·Lab on a Chip·Javeed Shaikh MohammedDavid T Eddington
Mar 1, 2005·Diabetes·Silvia Del GuerraPiero Marchetti
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·R A RitzelP C Butler
Jun 8, 2017·Frontiers in Cell and Developmental Biology·Piero MarchettiLorella Marselli
Oct 27, 2009·Journal of Proteome Research·Hanna K NyblomPeter Bergsten
Jul 14, 2021·Nature Metabolism·Jelena Kolic, James D Johnson

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