PMID: 9181521Mar 1, 1997Paper

Pulsatile patterns of melatonin secretion in patients with gonadotropin-releasing hormone deficiency: effects of testosterone treatment

Journal of Pineal Research
R LuboshitzkyP Lavie

Abstract

Recently, we have demonstrated that male patients with gonadotropin-releasing hormone (GnRH) deficiency had increased nocturnal melatonin secretion that decreased to normal levels during testosterone treatment. The purpose of the current study was to examine if the abnormally increased melatonin levels in these patients were associated with pulsatile secretory patterns, and, if these were modified during testosterone administration. Characteristics of nocturnal melatonin and luteinizing hormone (LH) secretion were compared in six normal young males, six males with idiopathic hypogonadotropic hypogonadism (IGD), and in six males with constitutional delayed puberty (DP). Patients were examined in the untreated state and following the administration of 250 mg testosterone enanthate/month for 4 months. Serum samples for melatonin and LH levels were obtained every 15 min from 19.00 hr to 07.00 hr in a controlled light-dark environment. Pulse detection and pulse characteristics were determined by the program ULTRA. In comparison with normal controls, untreated IGD patients showed significantly higher pulse frequency, lower relative increments and shorter half-life times for melatonin. Similar findings were observed in DP patients, al...Continue Reading

References

Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·G M VaughanJ W Sackman
Mar 1, 1992·Journal of Pineal Research·M A SheikheldinW M Palmer
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·M H SamuelsE C Ridgway
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·I Trinchard-Lugan, F Waldhauser
Apr 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R W RivestP C Sizonenko
Jan 1, 1988·Journal of Pineal Research·S F Pang, P C Yip

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Citations

Aug 18, 2004·Sleep Medicine Reviews·R Luboshizsky, P Lavie
Jan 16, 2007·Hormone Research·A Molina-CarballoA Muñoz-Hoyos
Jul 17, 1998·Clinical Endocrinology·M Ozata, Z Beyhan
May 23, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·R Luboshitzky, P Lavie
Mar 19, 2020·International Journal of Environmental Research and Public Health·Beata Rzepka-Migut, Justyna Paprocka
Nov 1, 2021·Biology of Reproduction·Ester Beltran-FrutosGiulia Brigante

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