Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.

Clinical Endocrinology
Laura I StirratRebecca M Reynolds

Abstract

Hypothalamic-pituitary-adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid pulsatility in pregnancy. We aimed to investigate the ultradian rhythm of glucocorticoid secretion during obese and lean pregnancy and nonpregnancy. Serum cortisol, cortisone, corticosterone and 11-dehydrocorticosterone were measured by LC-MS/MS from samples obtained at 10-minute intervals between 08.00-11.00 hours and 16.00-19.00 hours, from 8 lean (BMI <25 kg/m2 ) and 7 obese (BMI > 35 kg/m2 ) pregnant women between 16-24 weeks gestation and again at 30-36 weeks), and nonpregnant controls (lean n = 3, obese n = 4) during the luteal phase of their menstrual cycle. Interstitial fluid cortisol was measured by ELISA, from samples obtained using a portable microdialysis and automated collection device at 20-minute intervals over 24 hours. Serum cortisol AUC, highest peak and lowest trough increased significantly with gestation in lean and obese pregnant compared with nonpregnant subjects. Pulsatility of cortisol was detected i...Continue Reading

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Sep 2, 2017·Scientific Reports·Laura I StirratRebecca M Reynolds

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Citations

Sep 27, 2018·Endocrinology·Molly J Dickens, Jodi L Pawluski
Oct 12, 2018·Medicine and Science in Sports and Exercise·Robert M GiffordDavid R Woods
Feb 16, 2020·Endocrine Reviews·Stafford L LightmanBecky L Conway-Campbell
Jan 27, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Emma C JohnsRebecca M Reynolds
Feb 14, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Abdalla Ahmed, Paul Delgado-Olguin
Feb 26, 2019·Frontiers in Neuroendocrinology·John A Russell, Paula J Brunton
Jul 1, 2021·American Journal of Physiology. Endocrinology and Metabolism·Robert M GiffordRebecca M Reynolds
May 14, 2020·Current Vascular Pharmacology·A L FowdenA N Sferruzzi-Perri

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