Pulse cyclophosphamide therapy for inflammatory bowel disease

World Journal of Gastroenterology : WJG
Zsolt BartaMargit Zeher

Abstract

To assess the efficacy of intravenous cyclophosphamide pulse therapy for refractory inflammatory bowel disease (IBD). We included in our cohort eight patients with (moderate/severe) steroid refractory IBD (4 with ulcerative colitis and 4 with Crohn's disease). They all received 6 cycles of intravenous cyclophosphamide (800 mg) per month. Patients entered into remission after the second/third cyclophosphamide pulse. Disease activity decreased. There were no side effects and toxicity. All the patients went into long lasting remission. All Crohn's disease patients and 3 of 4 ulcerative colitis patients achieved complete remission. One patient with ulcerative colitis showed an impressive clinical response but did not enter into remission. For the maintenance, patients with Crohn's disease were treated with methotrexate (15 mg/wk) and patients with ulcerative colitis were treated with azathioprine (2.5 mg/kg body weight/d). Remission was maintained in all patients for 6 mo on the average. The drug was well tolerated. These findings suggest that aggressive immunosuppressive therapy may be useful in some refractory patients and further controlled study should be considered in order to fully evaluate this type of treatment as a potenti...Continue Reading

References

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May 2, 2000·Rheumatology·R A WattsC M Lockwood
Jun 1, 2001·Inflammatory Bowel Diseases·B E SandsD K Podolsky
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Citations

Dec 24, 2019·American Journal of Physiology. Renal Physiology·Nathan A HirshmanJ Todd Purves
Nov 8, 2016·World Journal of Gastroenterology : WJG·Linda S YangAlexander J Thompson
May 19, 2007·Alimentary Pharmacology & Therapeutics·Z BartaM Zeher
Aug 14, 2009·Expert Review of Gastroenterology & Hepatology·Glen A Doherty, Adam S Cheifetz
Jun 24, 2021·Journal of Crohn's & Colitis·Tim RaineGarret Cullen

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