PMID: 9169958Jun 1, 1997Paper

Pulse-dosing and conventional application of doxepin: effects on psychopathology and hypothalamus-pituitary-adrenal (HPA) system

Journal of Clinical Psychopharmacology
Michael DeuschleI Heuser

Abstract

It has been shown that a single pulse-dosing (PD) dose of clomipramine improves depressive symptoms. However, so far PD and conventional (CONV) application of antidepressants have never been directly compared for an extended period. We performed a double-blind study of PD and CONV application of doxepin (DOX) in depressed patients. After a 1-week placebo treatment, nine parents in the PD group received 250 mg of DOX every 6 days and placebo on the other days until day 39. Ten patients in the CONV group received increasing dosages of DOX until day 7 and 250 mg DOX on the other days for 39 days. Three dexamethasone (DEX)-suppression/corticotropin-releasing hormone (CRH)-stimulation tests were completed: (1)during the initial placebo period; (2)on day 9; and (3)on day 21. In the PD group, scores on the Hamilton Rating Scale for Depression (HAM-D) differed from baseline only after day 36 (17.1 +/- 7.0 vs. 22.7 +/- 2.8, p < 0.03). In the CONV group, however, HAM-D scores improved significantly after 2 days (22.8 +/- 7.2 vs. 26.5 +/- 5.7, p < 0.02) and continued to improve until day 39 (7.3 +/- 5.8). From day 25 to 39, there were significant differences between the HAM-D scores of the two groups. In the PD group, the decline of corti...Continue Reading

References

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Citations

Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marcus IsingFlorian Holsboer
Jul 20, 2002·Journal of Psychiatric Research·Martin HatzingerEdith Holsboer-Trachsler
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hiroshi KunugiMasahiko Mikuni
Sep 15, 2009·Journal of Psychiatric Research·Martha S McKay, Konstantine K Zakzanis
Feb 7, 2007·Journal of Neuroendocrinology·C Schüle
Feb 25, 2006·Journal of Psychiatric Research·Bettina Weber-HamannMichael Deuschle
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Apr 5, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Leonie MantheyFrans G Zitman
Feb 24, 1998·Journal of Clinical Psychopharmacology·M DeuschleI Heuser
Feb 26, 2010·Journal of Neurochemistry·Sylwia Kedracka-KrokMarta Dziedzicka-Wasylewska
Nov 6, 2013·Current Psychiatry Reports·Julio Fernandez-Mendoza, Alexandros N Vgontzas
Jun 3, 2011·Harvard Review of Psychiatry·Sonja Horstmann, Elisabeth B Binder

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