Pulse mode of laser photodynamic treatment induced cell apoptosis

Photodiagnosis and Photodynamic Therapy
Vladimir V KlimenkoMichael V Dubina

Abstract

One of the factors limiting photodynamic therapy (PDT) is hypoxia in tumor cells during photodynamic action. PDT with pulse mode irradiation and appropriate irradiation parameters could be more effective in the singlet oxygen generation and tissue re-oxygenation than continuous wave (CW) mode. We theoretically demonstrate differences between the cumulative singlet oxygen concentration in PDT using pulse mode and CW mode of laser irradiation. In vitro experimental results show that photodynamic treatment with pulse mode irradiation has similar cytotoxicity to CW mode and induces mainly cell apoptosis, whereas CW mode induces necrotic cell death. We assume that the cumulative singlet oxygen concentration and the temporal distribution of singlet oxygen are important in photodynamic cytotoxicity and apoptosis initiation. We expect our research may improve irradiation protocols and photodynamic therapy efficiency.

References

Mar 1, 1989·Photochemistry and Photobiology·B W Henderson, V H Fingar
Nov 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R B Veenhuizen, F A Stewart
Feb 15, 2000·Journal of Photochemistry and Photobiology. B, Biology·Y MiyamotoT Nishisaka
Nov 6, 2002·Lasers in Medical Science·K SeguchiM Kikuchi
Mar 28, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nancy L OleinickIrina Belichenko
Mar 28, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Kristjan PlaetzerPeter Hammerl
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Feb 19, 2004·Life Sciences·A B UzdenskyG V Ponomarev
Apr 15, 2006·Lasers in Surgery and Medicine·Barbara W HendersonJohn W Snyder
Jun 22, 2006·Lasers in Surgery and Medicine·Theresa M Busch
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Junkoh YamamotoHiroki Namba
Nov 23, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·E R M de HaasD J Robinson
Apr 11, 2008·Physics in Medicine and Biology·Brian C Wilson, Michael S Patterson
Jun 6, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Halina MojzisovaDaniel Brault
Mar 12, 2010·Journal of Biophotonics·Ken Kang-Hsin WangTimothy C Zhu
Jan 21, 2011·The Journal of Investigative Dermatology·Georgia A FrostDiona L Damian
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Oct 31, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Henriëtte S de BruijnDominic J Robinson
Mar 8, 2013·Journal of Photochemistry and Photobiology. B, Biology·Doris BachMartin Pichler
Jan 1, 2011·Cancers·Pawel MrozMichael R Hamblin

❮ Previous
Next ❯

Citations

Nov 2, 2019·Pharmaceuticals·Ludivine LarueCéline Frochot
Oct 20, 2020·Photochemistry and Photobiology·Teerasak DamrongrungruangArkom Kaewrawang
Mar 4, 2020·Photodiagnosis and Photodynamic Therapy·Ali Furkan Kamanli, Gökçen Çetinel
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kasama KanpittayaTeerasak Damrongrungruang
Jul 25, 2021·Cancers·José Francisco AlgorriJosé Miguel López-Higuera
Aug 15, 2021·Photodiagnosis and Photodynamic Therapy·Ali Furkan Kamanli, Gökçen Çetinel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Lasers in Surgery and Medicine
David KesselJohn J Reiners
Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Jiyao ChenQian Peng
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
P Wolf
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Junkoh YamamotoHiroki Namba
© 2022 Meta ULC. All rights reserved