Pulse pressure-dependent cerebrovascular eNOS regulation in mice

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Adeline RaignaultEric Thorin

Abstract

Arterial blood pressure is oscillatory; whether pulse pressure (PP) regulates cerebral artery myogenic tone (MT) and endothelial function is currently unknown. To test the impact of PP on MT and dilation to flow (FMD) or to acetylcholine (Ach), isolated pressurized mouse posterior cerebral arteries were subjected to either static pressure (SP) or a physiological PP (amplitude: 30 mm Hg; frequency: 550 bpm). Under PP, MT was significantly higher than in SP conditions ( p < 0.05) and was not affected by eNOS inhibition. In contrast, under SP, eNOS inhibition increased ( p < 0.05) MT to levels observed under PP, suggesting that PP may inhibit eNOS. At a shear stress of 20 dyn/cm2, FMD was lower ( p < 0.05) under SP than PP. Under SP, eNOS-dependent [Formula: see text] production contributed to FMD, while under PP, eNOS-dependent NO was responsible for FMD, indicating that PP favours eNOS coupling. Differences in FMD between pressure conditions were abolished after NOX2 inhibition. In contrast to FMD, Ach-induced dilations were higher ( p < 0.05) under SP than PP. Reactive oxygen species scavenging reduced ( p < 0.05) Ach-dependent dilations under SP, but increased ( p < 0.05) them under PP; hence, under PP, Ach promotes ROS produc...Continue Reading

References

Sep 1, 1991·Circulation Research·K FujiiF M Faraci
May 1, 1990·Circulation Research·J L Garcia-Roldan, J A Bevan
Jan 1, 1990·Circulation Research·F M Faraci, D D Heistad
Oct 1, 1995·Circulation Research·A C Ngai, H R Winn
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·G L BaumbachD D Heistad
Dec 1, 1996·The Annals of Thoracic Surgery·K TodaH Takano
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·N Thorin-Trescases, J A Bevan
May 13, 1999·The Annals of Thoracic Surgery·C BaufretonD Y Loisance
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T NakanoH Yasui
May 28, 2003·Journal of the American College of Cardiology·Roberto CeravoloFrancesco Perticone
Aug 30, 1962·The New England Journal of Medicine·H WILKENSF S HOFFMEISTER
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Akos Koller, Zsolt Bagi
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Robert D ShipleyJudy M Muller-Delp
Sep 7, 2005·Artificial Organs·Akira SezaiYukiyasu Sezai
Nov 19, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ton J Rabelink, Thomas F Luscher
Jan 28, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Helene GirouardCostantino Iadecola
Apr 6, 2006·Circulation·Ulrich Förstermann, Thomas Münzel
Jul 3, 2007·Journal of the American College of Cardiology·Michael F O'Rourke, Junichiro Hashimoto
Jun 5, 2008·Cell Metabolism·Costantino Iadecola, Robin L Davisson
Oct 28, 2008·American Journal of Physiology. Heart and Circulatory Physiology·L S A CapettiniV S Lemos
Feb 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Brandon T LarsenDavid D Gutterman
Jun 23, 2009·Trends in Pharmacological Sciences·Michael A HillIsmail Laher
Jul 10, 2009·Cardiovascular Research·Eric Thorin, Nathalie Thorin-Trescases
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Adrian GerickeNorbert Pfeiffer
May 28, 2011·Pflügers Archiv : European journal of physiology·Annick DrouinEric Thorin
Aug 17, 2011·The Journal of Thoracic and Cardiovascular Surgery·Frédéric PinaudChristophe Baufreton
Sep 20, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Virginie BolducEric Thorin
May 29, 2012·Cardiovascular Research·Gilles KauffensteinDaniel Henrion
Jun 29, 2012·Journal of Vascular Research·Akos Koller, Peter Toth
Aug 23, 2012·Best Practice & Research. Clinical Anaesthesiology·Gabriel Loor, Gonzalo Gonzalez-Stawinski
Jan 15, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew J Durand, David D Gutterman
Aug 28, 2013·Hypertension·Giuseppe Faraco, Costantino Iadecola
Nov 5, 2013·Current Pharmaceutical Design·Elke H Heiss, Verena M Dirsch
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Axel B K ThomsenEbbe Boedtkjer
Nov 28, 2013·Hypertension·Daniel J GreenDick H J Thijssen
Feb 12, 2014·The Journal of Biological Chemistry·Helmut Sies
Mar 20, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takashi TarumiRong Zhang

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Citations

Sep 25, 2017·Journal of Hypertension·Nataliya SadekovaHélène Girouard
Nov 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kurt J SmithDaniel J Green
Feb 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nathalie Thorin-TrescasesEric Thorin
Jan 10, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Leila HadjadjSzabolcs Várbíró
Mar 24, 2020·American Journal of Hypertension·Olivia de MontgolfierEric Thorin
Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Christopher R WoodmanAndreea Trache

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GraphPad
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