PMID: 9540219Apr 16, 1998Paper

Pulse radiolysis studies of melatonin and chloromelatonin

Journal of Photochemistry and Photobiology. B, Biology
J E RobertsJ F Wishart

Abstract

The endogenous indole melatonin and the melatonin receptor agonist 6-chloromelatonin block the proliferation of both dermal and uveal melanoma cells by mechanisms that may involve redox reactions. The interactions of hydrated electrons, the azide radical, hydroxyl radicals and superoxide with melatonin and its 6-chloro analogue have been studied using the technique of pulse radiolysis. The reaction rate constants of eaq- and N3 x with these compounds were found to be dependent on substitution at the sixth position. The rate constants for reaction of 6-chloromelatonin and melatonin with solvated electrons are 4.5 x 10(9) M-1 s-1 and 4.2 x 10(8) M-1 s-1, respectively. The reaction rate constants of N3 x with malatonin and chloromelatonin are 9.8 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1, respectively. Melatonin and 6-chloromelatonin react with hydroxyl radicals at near diffusion controlled rates (1.3 x 10(10) M-1 s-1, 8.2 x 10(9) M-1 s-1). Melatonin and 6-chloromelatonin did not react with superoxide radicals and we calculate an upper limit of 1.0 x 10(4) M-1 s-1 for the rate constant for reaction of melatonin and 6-chloromelatonin with superoxide ion.

References

Jul 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E J Land, W A Prütz
Nov 1, 1991·Melanoma Research·R GonzalezW A Robinson
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S ChristenR Stocker
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L Dubocovich
Aug 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I J Fidler, E S Kleinerman
Jun 1, 1983·Archives of Biochemistry and Biophysics·A SevanianS Montestruque
Jul 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·J E Roberts
Jul 7, 1995·The Journal of Biological Chemistry·M R GuntherR P Mason
Nov 17, 1994·Annals of the New York Academy of Sciences·J S Beckman
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Aug 1, 1994·Journal of the American Academy of Dermatology·A PignoneT Lotti
Feb 1, 1994·Neurochemistry International·P J MorganR Helliwell
Jan 1, 1993·Journal of Pineal Research·G J Maestroni
Jan 1, 1993·Journal of Pineal Research·S F SzeW K Liu
May 1, 1995·Journal of Pineal Research·C Carlberg, I Wiesenberg
Oct 1, 1995·Journal of Pineal Research·A Conti, G J Maestroni
Jan 1, 1996·Free Radical Biology & Medicine·K A MarshallB Halliwell
Feb 1, 1997·Melanoma Research·D N Hu, J E Roberts
Jan 1, 1997·Free Radical Biology & Medicine·Z MatuszakC F Chignell
Jun 1, 1996·Redox Report : Communications in Free Radical Research·B PoeggelerL R Barlow-Walden

❮ Previous
Next ❯

Citations

Dec 18, 2001·Journal of Photochemistry and Photobiology. B, Biology·J E Roberts
Sep 8, 2007·Journal of Photochemistry and Photobiology. B, Biology·Mingzhang LinKeichi Nakagawa
Jan 3, 2013·Journal of Pineal Research·Jae-Hyung ParkDae-Kyu Song
Jul 15, 2011·Journal of Pineal Research·Annia GalanoRussel J Reiter
May 7, 2011·Journal of Pineal Research·Catherine MarchettiDominique Bonnefont-Rousselot
Jan 20, 2011·Journal of Pineal Research·Dominique Bonnefont-RousselotMonique Gardès-Albert
Jul 26, 2014·Journal of Pineal Research·Hong-Mei Zhang, Yiqiang Zhang
Jun 14, 2003·Redox Report : Communications in Free Radical Research·Dominique Bonnefont-RousselotMonique Gardès-Albert
Jun 28, 2005·Journal of Pineal Research·J MekhloufiM Gardès-Albert
Apr 19, 2007·Journal of Pineal Research·Jamila MekhloufiDominique Bonnefont-Rousselot
Apr 27, 2010·Toxicology·Dominique Bonnefont-Rousselot, Fabrice Collin
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Jan 29, 2002·Free Radical Research·L TesoriereM A Livrea
Apr 11, 2017·The Journal of Physical Chemistry. B·Stanislav A PshenichnyukAlexei S Komolov
Jan 23, 2003·International Journal of Toxicology·Joan E Roberts
Oct 25, 2000·Photochemistry and Photobiology·J E RobertsC F Chignell
Jun 12, 2018·Journal of Pineal Research·Annia Galano, Russel J Reiter
Nov 24, 2018·Chemical Communications : Chem Comm·Claudio VallottoPeter J Sadler
Aug 3, 2002·Journal of Pineal Research·Dominique Bonnefont-RousselotMonique Gardès-Albert
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Russel J. Reiter
Oct 4, 2006·Free Radical Research·Fabienne PeyrotClaire Ducrocq
Nov 4, 2000·Journal of Biomedical Science·R J ReiterE Gitto
Jul 31, 2021·The Journal of Physical Chemistry Letters·Dongmei ZhangXinxing Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.