Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea.

Sleep & Breathing = Schlaf & Atmung
Jessie BakkerAlister Neill

Abstract

Non-invasive measurements of arterial stiffness including the augmentation index (AIx) and central blood pressure (BP) have been used to assess the cardiovascular health of patients with obstructive sleep apnoea (OSA), a well-established independent risk factor of cardiovascular disease. Continuous positive airway pressure (CPAP) can significantly reduce the AIx, but no studies have analysed the effect of auto-adjusting PAP (APAP) or studied morbidly obese patients with severe OSA at higher risk of cardiovascular disease. In this randomised, single-blinded crossover pilot trial, we aimed to compare the efficacy of CPAP with APAP (ResMed S8 Autoset II) in improving peripheral BP, central BP and the AIx, using SphygmoCor technology. Twelve severe OSA patients (mean±SD; apnoea-hypopnoea index, 75.8 ± 32.7; BMI, 49.9 ± 5.2 kg/m(2)) were consecutively recruited and received CPAP (mean pressure, 16.4 cm H(2)O) or APAP in random order for four nights at home, separated by a four-night washout. Cardiovascular measurements were taken at baseline, post-washout and following each treatment arm. The polysomnographically recorded residual apnoea-hypopnoea index and compliance to treatment were not significantly different between arms (p > 0...Continue Reading

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Jan 11, 2000·QJM : Monthly Journal of the Association of Physicians· Yasmin, M J Brown
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·W J RanderathK H Rühle
Jun 26, 2001·British Journal of Clinical Pharmacology·M F O'RourkeX J Jiang
Feb 21, 2002·Lancet·Kenneth F Schulz, David A Grimes
Mar 29, 2002·Lancet·Kenneth F Schulz, David A Grimes
May 23, 2002·American Journal of Hypertension·Luc M Van BortelChristian Thuillez
Aug 6, 2002·American Journal of Hypertension·Bruno M PannierKenji Takazawa
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·James J Oliver, David J Webb
Mar 18, 2003·Journal of Hypertension·Justine Ina Davies, Allan D Struthers
Feb 22, 2005·The Journal of Clinical Hypertension·Thomas G PickeringUNKNOWN Council on High Blood Pressure Research Professional and Public Education Subcommittee, American Heart Association
Apr 13, 2005·Respiration; International Review of Thoracic Diseases·Neşe DursunoğluZeki Kiliçaslan
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Nov 25, 2006·Experimental Physiology·J Woodrow WeissJianhua Huang
Jan 2, 2007·The European Respiratory Journal·W T McNicholasUNKNOWN Management Committee of EU COST ACTION B26
Jan 27, 2007·Sleep·Magdalena NowakRobert Meyrer
Jul 12, 2007·Clinical Science·Paul K HamiltonGary E McVeigh
Apr 12, 2008·Diabetes & Metabolism·P Boutouyrie
Jun 10, 2008·Journal of Clinical Nursing·Joseph P NoonRoger L Scott
Jul 26, 2008·The European Respiratory Journal·M KohlerR J O Davies
Jul 29, 2008·American Journal of Respiratory and Critical Care Medicine·Malcolm KohlerJohn R Stradling
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akiko NodaYasuo Koike
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kevin S HeffernanBo Fernhall
Dec 23, 2008·Lancet·T Douglas Bradley, John S Floras
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Motohiro Shimizu, Kazuomi Kario

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Citations

Jul 16, 2013·Sleep & Breathing = Schlaf & Atmung·Murat SunbulIbrahim Sari
Feb 7, 2015·Sleep & Breathing = Schlaf & Atmung·Ian W SeethoJohn P H Wilding
Apr 16, 2014·Journal of Sleep Research·Ian W SeethoJohn P H Wilding
Feb 1, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenta IgamiTakeshi Tanigawa
Apr 25, 2017·Metabolic Syndrome and Related Disorders·Anamil M KhiyamiSabyasachi Sen

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