Pulse wave velocity and cardiac autonomic function in type 2 diabetes mellitus

BMC Endocrine Disorders
Stamatina ChorepsimaNikolaos Tentolouris

Abstract

Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication of diabetes and has been associated with reduced aortic distensibility. However, the association of cardiac autonomic dysfunction with PWV is not known. In this study we examined the association between cardiac autonomic function and PWV in subjects with type 2 diabetes mellitus. A total of 290 patients with type 2 diabetes were examined. PWV was measured at the carotid-femoral segment with applanation tonometry. Central mean arterial blood pressure (MBP) was determined by the same apparatus. Participants were classified as having normal (n = 193) or abnormal (n = 97) PWV values using age-corrected values. Cardiac autonomic nervous system activity was determined by measurement of parameters of heart rate variability (HRV). Subjects with abnormal PWV were older, had higher arterial blood pressure and higher heart rate than those with normal PWV. Most of the values of HRV were significantly lower in subjects with abnormal than in those with normal PWV. Multivariate analysis, after controlling for various confounding factors, ...Continue Reading

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Citations

Oct 18, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Pinelopi GrigoropoulouNikolaos Tentolouris
May 24, 2018·Journal of Human Hypertension·Ioanna EleftheriadouNikolaos Tentolouris
May 13, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ji Won MinByung Ha Chung

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Methods Mentioned

BETA
percutaneous
coronary

Software Mentioned

BaroCor System
SPSS

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