Jan 17, 2013

Pulse wave velocity and cognitive decline in elders: the Health, Aging, and Body Composition study

Stroke; a Journal of Cerebral Circulation
Adina Zeki Al HazzouriHealth ABC Study

Abstract

Arterial stiffness is a measure of subclinical cardiovascular disease and increases with age. This study examines the association between arterial stiffness and cognitive decline in a cohort of older adults. A total of 2488 subjects with baseline measure of arterial stiffness (mean age, 74.2 years; 52.3% women) were prospectively followed over 9 years in the Health, Aging, and Body Composition Study. Arterial stiffness was measured as pulse wave velocity (PWV) and analyzed in tertiles. Cognitive function was assessed using the Modified Mini-Mental State examination at baseline and repeated at years 3, 5, 8, and 10. Lower Modified Mini-Mental State examination scores indicate worse function. We fit linear mixed models to examine longitudinal changes in cognitive function over the 9 years of follow-up and logistic regression models, restricted to 1331 participants, to examine cognitive impairment defined as a decrease of ≥5 points after 9 years. We adjusted for sociodemographics, Apoe4, and cardiovascular disease risk factors. The annual decrease in Modified Mini-Mental State examination scores was 0.30 points at low PWV (95% confidence interval [CI], -0.37 to -0.22), 0.46 points at middle PWV (95% CI, -0.54 to -0.39), and 0.45 p...Continue Reading

Mentioned in this Paper

Health Status
Memory for Designs Test
Incidence Studies
Senility
Cardiovascular Diseases
Longitudinal Survey
Population Surveillance
Cognition Disorders
Arterial Stiffness
Apolipoprotein E4 Measurement

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