Pulse wave velocity is associated with cognitive impairment in hemodialysis patients

Clinical Science
Susanne AngermannChristoph Schmaderer

Abstract

Cognitive impairment in hemodialysis patients is common and associated with adverse outcomes. So far, the underlying pathogenesis remains unclear. Therefore, we examined the potential relationship between cognitive impairment and three different categories of risk factors with particular focus on arterial stiffness measured by pulse wave velocity (PWV). A total of 201 chronic hemodialysis patients underwent cognitive testing under standardized conditions using the Montreal Cognitive Assessment (MoCA). Demographic data including cardiovascular risk factors, dialysis-associated factors as well as factors related to chronic kidney disease (CKD) were analyzed. To account for arterial stiffness, PWV was measured by ambulatory blood pressure monitoried with an oscillometric device that records brachial blood pressure along with pulse waves. In our cohort, 60.2% of patients showed pathological MoCA test results indicating cognitive impairment. PWV was significantly associated with cognitive impairment apart from age, educational level, diabetes, and hypercholesterolemia. High prevalence of cognitive impairment in hemodialysis patients was confirmed. For the first time, an association between cognitive impairment and arterial stiffness...Continue Reading

References

Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Dec 1, 1983·Journal of Clinical Neuropsychology·R P HartR L Adams
Apr 29, 1998·Journal of the American Geriatrics Society·J SugarmanR C Hubal
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J G Umans, N H Pliskin
May 23, 2002·American Journal of Hypertension·Luc M Van BortelChristian Thuillez
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Oct 28, 2004·Journal of the American Geriatrics Society·Manjula KurellaKristine Yaffe
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jun 6, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manjula KurellaGlenn M Chertow
Jul 26, 2006·Neurology·A M MurrayR L Kane
Jun 20, 2007·Hemodialysis International·Arema A PereiraMark J Sarnak
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Daniel A RakowskiKevin C Abbott
Sep 1, 2009·Transplantation Proceedings·F R Carrasco Barrientos
Oct 16, 2009·The New England Journal of Medicine·Manjula Kurella TamuraCharles E McCulloch
Mar 11, 2010·Blood Pressure Monitoring·Wolfgang WeiMarkus van der Giet
Mar 20, 2010·Journal of Human Hypertension·S WassertheurerD Magometschnigg
Mar 27, 2010·Journal of the American College of Cardiology·Charalambos VlachopoulosChristodoulos Stefanadis
Jun 10, 2010·European Heart Journal·UNKNOWN Reference Values for Arterial Stiffness' Collaboration
Jun 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Manjula Kurella TamuraUNKNOWN Frequent Hemodialysis Network Trial Group
Jul 27, 2010·Blood Pressure Monitoring·Pascal M L Franssen, Ben P M Imholz
Sep 24, 2010·Kidney International·Manjula Kurella Tamura, Kristine Yaffe
Dec 15, 2010·American Journal of Nephrology·Lena M GiangMark J Sarnak
Dec 27, 2011·International Journal of Cardiology·Michael ReppelKai Mortensen
Jan 27, 2012·Journal of Hypertension·Luc M Van BortelUNKNOWN European Network for Noninvasive Investigation of Large Arteries
May 25, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Leonella LuzardoJosé Boggia
Aug 14, 2012·Journal of Alzheimer's Disease : JAD·Simon W Rabkin
Feb 22, 2014·Dementia and Geriatric Cognitive Disorders·Susanne TholenTimo Grimmer
Sep 4, 2014·Journal of Alzheimer's Disease : JAD·Angelo Scuteri, HongYu Wang
Oct 30, 2014·Journal of Alzheimer's Disease : JAD·Adina Zeki Al Hazzouri, Kristine Yaffe
Dec 4, 2014·Current Opinion in Nephrology and Hypertension·Raymond R Townsend
Jan 31, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Antonios KarpetasAnastasios N Lasaridis
Aug 26, 2015·American Journal of Hypertension·Evaggelia K AissopouAthanassios D Protogerou

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Citations

Dec 1, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anita van ZwietenUNKNOWN COGNITIVE-HD study investigators
Nov 16, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Justin LeeJawed Fareed
Feb 6, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Thaís Malucelli Amatneeks, Amer Cavalheiro Hamdan
Feb 29, 2020·Journal of the American Heart Association·Celia Alvarez-BuenoIvan Cavero-Redondo
May 8, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Thaís Malucelli Amatneeks, Amer Cavalheiro Hamdan
May 16, 2020·Frontiers in Cardiovascular Medicine·Catherine A ElliotCatherine A Lizamore
Jul 1, 2017·Clinical Science·Eve Miller-Hodges, Neeraj Dhaun
Nov 10, 2018·Journal of Alzheimer's Disease : JAD·Susanne AngermannChristoph Schmaderer

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