Pulse Waves in the Lower Extremities as a Diagnostic Tool of Peripheral Arterial Disease and Predictor of Mortality in Elderly Chinese

Hypertension
Chang-Sheng ShengJi-Guang Wang

Abstract

Patients with peripheral arterial disease may have elongated upstroke time in pulse waves in the lower extremities. We investigated upstroke time as a diagnostic tool of peripheral arterial disease and predictor of mortality in an elderly (≥60 years) Chinese population. We recorded pulse waves at the left and right ankles by pneumoplethysmography and calculated the percentage of upstroke time per cardiac cycle. Diagnostic accuracy was compared with the conventional ankle-brachial index method (n=4055) and computed tomographic angiography (34 lower extremities in 17 subjects). Upstroke time per cardiac cycle at baseline (mean±SD, 16.4%±3.1%) was significantly (P<0.0001) associated with ankle-brachial index in men (n=1803; r=-0.44) and women (n=2252; r=-0.32) and had an overall sensitivity and specificity of 86% and 80%, respectively, for the diagnosis of peripheral arterial disease (upstroke time per cardiac cycle, ≥21.7%) in comparison with computed tomographic angiography. During 5.9 years (median) of follow-up, all-cause and cardiovascular deaths occurred in 366 and 183 subjects, respectively. In adjusted Cox regression analyses, an upstroke time per cardiac cycle ≥21.7% (n=219; 5.4%) significantly (P<0.0001) predicted total ...Continue Reading

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Citations

Nov 30, 2018·Journal of the American Heart Association·Ikuno TakahashiWaka Ohishi
Feb 25, 2020·The Journal of Clinical Hypertension·Kazuomi Kario
Jun 27, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Li-Hsin ChangLiang-Yu Lin
Apr 18, 2021·Journal of Vascular Surgery·Xixiang GaoAlan Dardik
Jun 5, 2019·Journal of Vascular Surgery·Michael S ConteUNKNOWN GVG Writing Group
Jun 11, 2021·Circulation Research·Eddie L HacklerKhendi T White Solaru
Jun 1, 2021·International Angiology : a Journal of the International Union of Angiology·Tjun Y TangChuo R Leong

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