Pulsed electromagnetic fields combined with a collagenous scaffold and bone marrow concentrate enhance osteochondral regeneration: an in vivo study

BMC Musculoskeletal Disorders
F VeronesiM Fini

Abstract

The study aimed to evaluate the combined effect of Pulsed Electromagnetic Field (PEMF) biophysical stimulation and bone marrow concentrate (BMC) in osteochondral defect healing in comparison to the treatment with scaffold alone. An osteochondral lesion of both knees was performed in ten rabbits. One was treated with a collagen scaffold alone and the other with scaffold seeded with BMC. Half of the animals were stimulated by PEMFs (75 Hz, 1.5 mT, 4 h/day) and at 40 d, macroscopic, histological and histomorphometric analyses were performed to evaluate osteochondral defect regeneration. Regarding cartilage, the addition of BMC to the scaffold improved cell parameters and the PEMF stimulation improved both cell and matrix parameters compared with scaffold alone. The combination of BMC and PEMFs further improved osteochondral regeneration: there was an improvement in macroscopic, cartilage cellularity and matrix parameters and a reduction in the percentage of cartilage under the tidemark. Epiphyseal bone healing improved in all the osteochondral defects regardless of treatment, although PEMFs alone did not significantly improve the reconstruction of subchondral bone in comparison to treatment with scaffold alone. Results show that B...Continue Reading

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Citations

Jun 24, 2017·Journal of Cellular Physiology·Francesca SalamannaMilena Fini
Oct 13, 2017·Tissue Engineering. Part B, Reviews·Kenjiro Iwasa, A Hari Reddi
Jan 16, 2019·International Orthopaedics·Leo MassariRuggero Cadossi
Oct 27, 2018·Journal of Cellular Physiology·Melania MaglioMilena Fini
Sep 27, 2018·International Journal of Biomaterials·Carlo GalliStefano Guizzardi
Jun 24, 2020·World Journal of Orthopedics·Giada LulliniGiulio Maria Marcheggiani Muccioli
Apr 8, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Mit Balvantray BhavsarJohn H Barker
May 16, 2018·The American Journal of Sports Medicine·Rikiya BabaNorimasa Iwasaki
Oct 1, 2020·Biotechnology and Bioengineering·Matilde TschonGianluca Giavaresi
Oct 20, 2020·Bone & Joint Research·Carlotta Perucca OrfeiLaura de Girolamo
Jan 21, 2021·International Journal of Molecular Sciences·Katia VaraniMonica De Mattei

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