Pulsed estrogen therapy prevents post-OVX porcine dura mater microvascular network weakening via a PDGF-BB-dependent mechanism

PloS One
Olga V GlinskiiVladislav V Glinsky

Abstract

In postmenopausal women, estrogen (E2) deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM). The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX) DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a...Continue Reading

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Citations

Feb 18, 2016·The Journal of Nutritional Biochemistry·Sin-Jin LiChing-Yi Chen
Mar 18, 2015·Experimental and Therapeutic Medicine·Yonghua LiY U Zhou
Jun 14, 2017·The Journal of International Medical Research·Lanhua TangShushan Zhao
Apr 24, 2018·European Journal of Clinical Investigation·Chia-Yu WangChing-Yi Chen
Nov 3, 2017·Frontiers in Neurology·Olga V GlinskiiVladislav V Glinsky

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Methods Mentioned

BETA
hormone replacement therapy
Hormone
hormone replacement
blood collection
Antibody
Antibody Array
ELISA

Software Mentioned

Fovea
ImageJ
Discovery Series Quantity One 1 - D Analysis
Fovea Pro Photoshop
Adobe Photoshop
RayBio® Antibody Array Analysis Tool
GraphPad

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