Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.

Frontiers in Neurology
Darrian RiceSuhrud M Rajguru

Abstract

A variety of stimuli activating vestibular end organs, including sinusoidal galvanic vestibular stimulation, whole body rotation and tilt, and head flexion have been shown to evoke significant changes in blood pressure (BP) and heart rate (HR). While a role for the vertical semicircular canals in altering autonomic activity has been hypothesized, studies to-date attribute the evoked BP and HR responses to the otolith organs. The present study determined whether unilateral activation of the posterior (PC) or anterior (AC) semicircular canal is sufficient to elicit changes in BP and/or HR. The study employed frequency-modulated pulsed infrared radiation (IR: 1,863 nm) directed via optical fibers to PC or AC of adult male Long-Evans rats. BP and HR changes were detected using a small-animal single pressure telemetry device implanted in the femoral artery. Eye movements evoked during IR of the vestibular endorgans were used to confirm the stimulation site. We found that sinusoidal IR delivered to either PC or AC elicited a rapid decrease in BP and HR followed by a stimulation frequency-matched modulation. The magnitude of the initial decrements in HR and BP did not correlate with the energy of the suprathreshold stimulus. This resp...Continue Reading

References

Apr 1, 1988·The American Journal of Physiology·W W Blessing
Aug 1, 1969·Experimental Neurology·P C Tang, B E Gernandt
Jan 1, 1993·The American Journal of Physiology·I JeskeD J Reis
Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·F CostaI Biaggioni
Jun 19, 1996·Annals of the New York Academy of Sciences·B J Yates
Jan 1, 1997·Experimental Brain Research·S F WoodringB J Yates
Apr 1, 1997·The American Journal of Physiology·T L Shortt, C A Ray
Dec 24, 1997·Journal of the Autonomic Nervous System·J CuiY Wada
Oct 2, 1998·The American Journal of Physiology·C A RayS L Steele
May 8, 1999·Journal of Applied Physiology·B J JianB J Yates
Aug 11, 2000·Journal of Neuroscience Methods·J S StahlC I De Zeeuw
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Natarajan, S F Morrison
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J CuiS Mori
Mar 27, 2002·Experimental Brain Research·H KaufmannB Cohen
Mar 1, 2003·Acta Physiologica Scandinavica·C A Ray, J R Carter
Mar 11, 2003·The Journal of Physiology·Nathan T KuipersChester A Ray
Apr 12, 2003·Experimental Brain Research·A ThurrellA M Bronstein
Sep 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Taro Miyahara GotohHironobu Morita
May 11, 2004·Journal of Applied Physiology·Richard C Fitzpatrick, Brian L Day
Dec 25, 2004·The Journal of Physiology·Ian CathersRichard C Fitzpatrick
Mar 26, 2005·Optics Letters·Jonathon WellsAnita Mahadevan-Jansen
May 14, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kathrine Jáuregui-RenaudG Michael Halmagyi
Jun 10, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Giosuè GulliRoger Hainsworth
Nov 26, 2005·Experimental Brain Research·Andrei VoustianioukBernard Cohen
Mar 11, 2006·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer
May 25, 2006·Experimental Brain Research·Leah R BentVaughan G Macefield
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jul 1, 2006·The Journal of Physiology·T D WilsonB J Yates
Jul 28, 2006·Lasers in Surgery and Medicine·Agnella D IzzoJoseph T Walsh
Jun 9, 2007·Journal of Applied Physiology·Hong ZhuWu Zhou
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Charity L SauderChester A Ray
Feb 20, 2009·Experimental Brain Research·Yosuke NakamuraYasuaki Kawai
Sep 25, 2009·BMC Neuroscience·Jorge M SerradorScott J Wood
Oct 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K J YavorcikB J Yates
Mar 1, 1973·Applied Optics·G M Hale, M R Querry
Jul 7, 2010·Hearing Research·Suhrud M RajguruClaus-Peter Richter
Jan 19, 2011·The Journal of Physiology·Suhrud M RajguruRichard D Rabbitt
Mar 5, 2011·Experimental Brain Research·Bernard CohenSergei B Yakushin
Oct 22, 2011·Epilepsy & Behavior : E&B·Rubens FazanNorberto Garcia-Cairasco

❮ Previous
Next ❯

Software Mentioned

Ponemah
MATLAB
Ponemah ( DSI )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.