Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials

Materials
Ruxandra-Ioana SchiteaCristina Busuioc

Abstract

The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a conse...Continue Reading

References

Mar 5, 2005·Journal of Materials Science. Materials in Medicine·Ruilin Du, Jiang Chang
Dec 13, 2005·Biomaterials·Qizhi Z ChenAldo R Boccaccini
Sep 11, 2007·Biomolecular Engineering·Halina PodbielskaUwe Bindig
Mar 23, 2011·Acta Biomaterialia·Mohamed N RahamanAntoni P Tomsia
May 5, 2012·Journal of Zhejiang University. Science. B·Dan-li FuLi Liu
Aug 28, 2012·Acta Biomaterialia·Julian R Jones
Nov 8, 2015·International Journal of Pharmaceutics·Georgeta VoicuCristina Busuioc
May 24, 2017·Materials Science & Engineering. C, Materials for Biological Applications·P PísaříkJ Šepitka
Mar 17, 2018·Journal of Functional Biomaterials·Elisa FiumeFrancesco Baino
Jul 22, 2018·Tissue Engineering. Part a·Yu Seon KimAntonios G Mikos
Feb 26, 2019·Journal of Biomaterials Science. Polymer Edition·Ashley Thomas, Japes Bera
Jun 8, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Alireza Zandi KarimiRobin A L Drew
Aug 10, 2019·Journal of the Mechanical Behavior of Biomedical Materials·M S Kairon MubinaL Saranya
Sep 11, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Gurbinder KaurOana Bretcanu
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Luis A Haro DurandAlejandro Gorustovich

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning
X-ray
infrared spectroscopy
fluorescence microscopy

Software Mentioned

ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved