Pulsed light irradiation improves behavioral outcome in a rat model of chronic mild stress

Lasers in Surgery and Medicine
Xingjia WuJuanita J Anders

Abstract

Transcranial laser therapy (TLT) has been used successfully for the treatment of stroke in animal models and clinical trials. These results support the hypothesis that TLT could be used to treat other central nervous system conditions, such as depression. Current therapy for depression emphasizes pharmaco-therapeutics. However, these interventions often cause unwanted side effects. Here, TLT as a treatment for depression was studied in a rat model of chronic mild stress (CMS). Wistar rats were randomized into four experimental groups (n = 8): (1) No-stress; (2) stress without treatment (Stress); (3) stress treated with an antidepressant (Drug); and (4) stress treated with TLT (TLT). The rats in the stress groups were exposed sequentially to a variety of mild stressors for 8 weeks. Rats were weighed weekly. After 5 weeks of stressing, the Drug group received a daily injection of fluoxetine (10 mg/kg), and the TLT group was irradiated transcranially 3 times a week (810 nm wavelength laser, 3 mm diameter probe, 350 mW peak power, 100 Hz with 20% duty cycle, 2-minute treatment time, 120 J/cm(2) average energy density on skin surface). After 3 weeks of treatment, a forced swimming test (FST) was performed and recorded for behavioral...Continue Reading

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Citations

Jun 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jian-Hua LiuWen-Bin Fu
Jun 14, 2013·Cognitive, Affective & Behavioral Neuroscience·Matthew BoykoAlexander Zlotnik
Jan 31, 2014·Photomedicine and Laser Surgery·Andrei P Sommer, Mario A Trelles
Mar 17, 2015·Lasers in Surgery and Medicine·Clark E TedfordJuanita Anders
Nov 6, 2012·Brain Research·Matthew BoykoAlexander Zlotnik
Oct 19, 2016·BBA Clinical·Michael R Hamblin
Jan 13, 2018·Molecular Neurobiology·Farzad SalehpourMichael R Hamblin
Oct 23, 2018·Photomedicine and Laser Surgery·Paolo CassanoDan V Iosifescu
Feb 24, 2017·Reviews in the Neurosciences·Farzad Salehpour, Seyed Hossein Rasta
Feb 12, 2017·Photomedicine and Laser Surgery·Dionyssios MintzopoulosMarc J Kaufman
Oct 28, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Paolo CassanoDan V Iosifescu
Dec 1, 2018·ACS Chemical Neuroscience·Svitlana M LevchenkoParas N Prasad

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