Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para -Hydrogen

ChemistryOpen
Sergey KorchakStefan Glöggler

Abstract

Diseases such as Alzheimer's and cancer have been linked to metabolic dysfunctions, and further understanding of metabolic pathways raises hope to develop cures for such diseases. To broaden the knowledge of metabolisms in vitro and in vivo, methods are desirable for direct probing of metabolic function. Here, we are introducing a pulsed nuclear magnetic resonance (NMR) approach to generate hyperpolarized metabolites within seconds, which act as metabolism probes. Hyperpolarization represents a magnetic resonance technique to enhance signals by over 10 000-fold. We accomplished an efficient metabolite hyperpolarization by developing an isotopic labeling strategy for generating precursors containing a favorable nuclear spin system to add para-hydrogen and convert its two-spin longitudinal order into enhanced metabolite signals. The transfer is performed by an invented NMR experiment and 20 000-fold signal enhancements are achieved. Our technique provides a fast way of generating hyperpolarized metabolites by using para-hydrogen directly in a high magnetic field without the need for field cycling.

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Citations

Mar 25, 2020·Angewandte Chemie·Baptiste JoallandEduard Y Chekmenev
Nov 27, 2018·NMR in Biomedicine·Jaspal SinghZoltan Kovacs
Oct 16, 2019·Physical Chemistry Chemical Physics : PCCP·Sergey KorchakStefan Glöggler
Jul 28, 2019·Chemistry : a European Journal·Lukas KaltschneeStefan Glöggler
Jan 16, 2021·Physical Chemistry Chemical Physics : PCCP·Stephan BernerJan-Bernd Hövener
Feb 17, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Neil J StewartShingo Matsumoto
Mar 17, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Vladimir V ZhivonitkoAxel Schulz
Apr 21, 2021·Physical Chemistry Chemical Physics : PCCP·Bogdan A RodinKonstantin L Ivanov
May 1, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Oleg G SalnikovEduard Y Chekmenev
Jun 25, 2021·Chemical Science·Sergey KorchakStefan Glöggler
May 31, 2019·Journal of the American Chemical Society·James EillsMarcel Utz
Aug 1, 2019·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Oleg G SalnikovEduard Y Chekmenev
Dec 1, 2021·Physical Chemistry Chemical Physics : PCCP·Andreas B SchmidtAndrey N Pravdivtsev
Dec 8, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Andrey N PravdivtsevAndreas B Schmidt

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

ESOTHERIC
SABRE
INEPT

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