Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Daniel Torres-MendozaMarcelino Gutierrez

Abstract

Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.

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Citations

Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
May 13, 2021·Journal of Natural Products·Lorena CoronadoCarmenza Spadafora

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Datasets Mentioned

BETA
MG018253

Methods Mentioned

BETA
ELISA
light microscopy
flow cytometry
FCS

Software Mentioned

FCS Express
Excel
Basic Local Alignment Search Tool ( BLAST
FloMax

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