Punch card programmable microfluidics

PloS One
George Korir, Manu Prakash

Abstract

Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series of holes in punched paper tapes, we demonstrate independent control of 15 on-chip pumps with enhanced mixing, normally-closed valves and a novel on-demand impact-based droplet generator. We demonstrate robustness of operation by encodi...Continue Reading

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Citations

Nov 26, 2015·Analytical Chemistry·Damith E W PatabadigeChristopher T Culbertson
Oct 22, 2015·Acta Biochimica Et Biophysica Sinica·Michael McCarthyAlemayehu A Gorfe
Jul 14, 2017·Lab on a Chip·Ho Nam ChanHongkai Wu
Oct 19, 2016·Lab on a Chip·Jason C HarperThayne L Edwards
Aug 1, 2018·Lab on a Chip·Peter ThurgoodKhashayar Khoshmanesh
Jan 11, 2019·Electrophoresis·Xinjie ZhangNan Xiang
Jul 30, 2019·Lab on a Chip·Peter ThurgoodKhashayar Khoshmanesh

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