Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats

Spine
K Olmarker

Abstract

Changes in spontaneous behavior was studied in rats after a controlled puncture of a lumbar intervertebral disc. To study if puncture of a lumbar disc would induce recordable changes in spontaneous pain behavior. Anular tears are common and may be found both in patients with low back pain and in asymptomatic patients. It has been suggested that anular injury may relate to low back pain either by stimulation of local sensory receptors in the posterior part of the anulus fibrosus or by ingrowth of newly formed nerve fibers into the deeper parts of the disc. The objective of the study was to analyze if a controlled puncture of a lumbar intervertebral disc might induce recordable changes in spontaneous behavior of rats. After anesthesia, the L4-L5 disc was punctured in 10 rats. Ten other rats received sham surgery. Spontaneous behavior was assessed at days 1, 3, 7, 14, and 21 after surgery. Statistically significant differences in behavior were seen at all days analyzed. Most consistent were increases in "grooming" and in "wet-dog shakes." Puncture of a lumbar intervertebral disc in the rat produces changes in spontaneous behavior mainly seen as increased "grooming" and "wet-dog shakes," 2 behaviors that have been suggested to indi...Continue Reading

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Citations

Jul 27, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ryo OhtaMitsuo Ochi
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
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Jun 26, 2013·Spine·Oscar FinskasKjell Olmarker
Nov 28, 2015·The Spine Journal : Official Journal of the North American Spine Society·Alon LaiJames C Iatridis
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Oct 12, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zemin LiZhaomin Zheng
Mar 4, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alon LaiJames C Iatridis
Sep 5, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Daisuke FukuiHiroshi Yamada
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Sep 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Changgui ShiHee-Jeong Im
Sep 22, 2019·Regional Anesthesia and Pain Medicine·Vaskar DasAsokumar Buvanendran
Aug 21, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fubiao YeZhaomin Zheng
Nov 27, 2019·Spine Surgery and Related Research·Hiroki UshirozakoYukihiro Matsuyama
Jul 24, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Shota YomogidaShin-Ichi Konno
May 15, 2020·Spine Surgery and Related Research·Satoshi UjigoKjell Olmarker
Jul 4, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Haowen CuiZhaomin Zheng
Nov 12, 2020·Experimental Biology and Medicine·Demissew Shenegelegn MernClaudius Thomé
Jul 4, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Magali MillecampsLaura S Stone

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