Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet

Oxidative Medicine and Cellular Longevity
Dana AtrahimovichSoliman Khatib

Abstract

Polyphenols are consumed daily in the human diet and are associated with reduced risk of a number of chronic diseases, including cancer, cardiovascular disease, and diabetes. Traditionally, the health benefits of polyphenols have been attributed to their antioxidant activity, but many studies might be hampered by oral administration and insignificant bioavailability. Rather than exerting a direct antioxidant effect, the mechanisms by which polyphenols express their beneficial effect seem to involve their interaction with proteins. The present study is aimed at broadening and confirming our recently published in vitro results showing that polyphenols may reduce atherosclerosis risk via interaction with proteins and lipoproteins related to atherosclerosis. The biological functions of punicalagin and quercetin in relation to glucose and lipid levels, paraoxonase 1 (PON1) activity, and inflammation were examined in vivo. Mice were fed a high-fat diet (HFD) for 12 weeks, and during the last 4 weeks, they received subcutaneous treatments via implanted minipumps, which released physiological concentrations of punicalagin, quercetin, or atorvastatin (as a positive control) daily into the serum. The HFD reduced serum PON1 activity, wher...Continue Reading

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Citations

Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qian DengJingui Xue
Nov 12, 2020·Pharmaceuticals·Sanaa AlmowalladAlexandre Prola
Jul 16, 2021·Frontiers in Cell and Developmental Biology·Gulinigaer AnwaierRong Qi
Jan 15, 2022·Bioscience Reports·Yibin ZengWuqing Wang

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Methods Mentioned

BETA
Assay
ELISA
Fluorescence

Software Mentioned

GraphPad Prism

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