PMID: 8600428Mar 1, 1996Paper

Pupillary response to tropicamide in patients with Alzheimer disease

Ophthalmology
D N LoupeH F Edelhauser

Abstract

To determine whether pupillary responses to dilute tropicamide could be used as a diagnostic test for Alzheimer disease (AD). The authors also investigated whether concurrent use of an oral acetylcholinesterase inhibitor (tacrine) alters the pupillary response to dilute tropicamide in patients with AD, and whether pupillary responses to dilute tropicamide differ in young versus older control subjects. Pupillary diameter and area of both eyes were measured in light and darkness, at 10-minute intervals for 40 minutes after random instillation of 0.01% tropicamide to one eye. Four groups of subjects were studied: 9 patients with AD, 10 who were treated with tacrine, 11 older control subjects, and 10 young control subjects. Mean change in anisocoria was not significantly different among groups at any of the measurement time points. Mean percent change in diameter of the treated eyes showed a trend toward faster maximum dilatation in the AD groups, but change in pupillary measurements did not identify individuals with AD. Pupillary response to dilute tropicamide did not effectively distinguish individual patients with AD from young or older control subjects.

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Citations

Nov 17, 2007·Aging Clinical and Experimental Research·Dimitris F FotiouFotis Fotiou
Jul 26, 2008·Archives of Gerontology and Geriatrics·L CaputoC Vergani
Jun 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F FotiouA Palikaras
Feb 6, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Eric GranholmBoris Vukov
Feb 13, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·K FountoulakisC Ierodiakonou
Aug 21, 2003·Neurobiology of Aging·Atsuhiko IijimaYukito Shinohara
Jun 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·R PrettymanE Szabadi
Dec 7, 2013·Survey of Ophthalmology·Radouil Tzekov, Michael Mullan
Jul 7, 2011·Journal of Clinical Pharmacy and Therapeutics·O MatouskovaF Perlik
Sep 19, 2003·Neurologic Clinics·Gregory R Jackson, Cynthia Owsley
Mar 10, 2015·Aging Clinical and Experimental Research·Dimitrios FotiouMaria Nakou
Feb 13, 1999·Journal of the American Geriatrics Society·A TakagiM Miyao
May 6, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·D F FotiouA Karlovasitou
Apr 30, 2019·Frontiers in Neurology·Pratik S ChouguleDan Milea
Mar 3, 2009·European Journal of Ophthalmology·Catherine BrozouPeriklis Brazitikos

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