Pupillography refines the diagnosis of diabetic autonomic neuropathy

Journal of the Neurological Sciences
Matthias DütschMax Josef Hilz

Abstract

Although diabetic autonomic neuropathy involves most organs, diagnosis is largely based on cardiovascular tests. Light reflex pupillography (LRP) non-invasively evaluates pupillary autonomic function. We tested whether LRP demonstrates autonomic pupillary dysfunction in diabetics independently from cardiac autonomic neuropathy (CAN) or peripheral neuropathy (PN). In 36 type-II diabetics (39-84 years) and 36 controls (35-78 years), we performed LRP. We determined diameter (PD), early and late re-dilation velocities (DV) as sympathetic parameters and reflex amplitude (RA) and constriction velocity (CV) as parasympathetic pupillary indices. We assessed the frequency of CAN using heart rate variability tests and evaluated the frequency of PN using neurological examination, nerve conduction studies, thermal and vibratory threshold determination. Twenty-eight (77.8%) patients had abnormal pupillography results, but only 20 patients (56%) had signs of PN or CAN. In nine patients with PN, only pupillography identified autonomic neuropathy. Four patients had pupillary dysfunction but no CAN or PN. In comparison to controls, patients had reduced PD, late DV, RA and CV indicating sympathetic and parasympathetic dysfunction. The incidence ...Continue Reading

References

Nov 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·H FruhstorferW C Schmidt
Sep 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·J M Goldberg, U Lindblom
Sep 30, 1978·British Medical Journal·S E SmithP H Sönksen
Sep 1, 1992·Medical & Biological Engineering & Computing·D P JonesS R Scicinski
Jan 1, 1992·Journal of Diabetes and Its Complications·D ZieglerF Lessmann
Dec 1, 1990·The Quarterly Journal of Medicine·P J Watkins
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·S A Smith, R R Dewhirst
Jan 1, 1985·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·S IshikawaK Mukuno
Feb 1, 1983·The British Journal of Ophthalmology·S A Smith, S E Smith
May 1, 1983·Diabetologia·S A Smith, S E Smith
Jan 1, 1981·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·E AlexandridisH Krastel
Sep 5, 1995·Journal of the Autonomic Nervous System·V S Gavriysky
Apr 1, 1995·Journal of the Neurological Sciences·M J HilzA Berić
Nov 1, 1994·Diabetes Research and Clinical Practice·S J Piha, J P Halonen
Jan 1, 1994·Nursing Research·S L MerrittP W Mercer
Dec 1, 1996·Journal of Neuropathology and Experimental Neurology·P J Dyck, C Giannini
Sep 19, 1998·Journal of the Neurological Sciences·M J HilzB Neundörfer
Jan 9, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M J HilzE H Kolodny
Sep 14, 1999·Klinische Monatsblätter für Augenheilkunde·T Gronow, W H Zangemeister
Sep 7, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·A S WinklerP J Watkins
Feb 15, 2001·European Journal of Internal Medicine·N TentolourisN Katsilambros
Feb 28, 2002·Journal of the Neurological Sciences·M DütschF B Axelrod

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Citations

Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·James T TaylorRobert Mioduszewski
Mar 10, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Cory Toth, William A Fletcher
Jul 21, 2012·Biomedical Engineering Online·Paolo MelilloFrancesca Simonelli
Jun 24, 2008·Cutaneous and Ocular Toxicology·Paul A DabischSandra Thomson
May 21, 2014·Cranio : the Journal of Craniomandibular Practice·Annalisa MonacoDavide Pietropaoli
Apr 6, 2016·The American Journal of Tropical Medicine and Hygiene·Anthony HalperinUNKNOWN Chagas Working Group in Bolivia and Peru
Feb 7, 2009·Journal of the Neurological Sciences·Karl-Jürgen BärMichael Karl Boettger
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul A DabischSandra Thomson
Mar 18, 2015·Clinical EEG and Neuroscience·Claus ReinsbergerBarbara A Dworetzky
Mar 14, 2018·Diagnostics·Charlotte A Hall, Robert P Chilcott
Oct 12, 2012·Muscle & Nerve·Ferhat EvliyaogluAhmet Z Burakgazi
Aug 11, 2018·Veterinary Ophthalmology·Braidee C FooteJessica M Stine
Mar 27, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Melo BeirãoPaulo Torres
Mar 25, 2020·Diabetology International·Hideyuki SasakiPhillip A Low
Apr 6, 2018·Scientific Reports·Mukesh JainRajiv Raman
Mar 19, 2019·Medicine·Hae-Young Lopilly ParkChan Kee Park
Mar 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul A DabischSandra A Thomson
Mar 12, 2019·Frontiers in Neurology·Carina KelbschBarbara J Wilhelm
Aug 20, 2021·Investigative Ophthalmology & Visual Science·Sarah R SheskeyCheng-Mao Lin

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