PMID: 11922402Apr 2, 2002Paper

Pure antiestrogens and breast cancer

Current Medical Research and Opinion
A E Elkak, K Mokbel

Abstract

Tamoxifen, which is the most commonly used drug for treatment of breast cancer, has both estrogen agonist and antagonist actions. Pure antiestrogens are devoid of any estrogen agonist effects. ICI 182,780 (fulvestrant) (Faslodex) and ICI 164,384 are competitive inhibitors of estrogen by binding to the estrogen receptor (ER). Preclinical and clinical studies show that fulvestrant and ICI 164,384 are more potent than tamoxifen in inhibiting the growth of breast cancer cells. They are devoid of any estrogen-agonist action on the uterus and vagina but lack the beneficial effects of tamoxifen on the bone and serum lipid profile. Fulvestrant is the first pure antiestrogen to complete phase III clinical trials. Such studies have shown that fulvestrant is at least as good as anastrozole in the treatment of post-menopausal women with advanced breast cancer who had relapsed or progressed on prior endocrine therapy. The drug was well tolerated and only minor side-effects were reported. Its potential role in the adjuvant setting will be determined by its adverse effects on bone mass and serum lipids. EM-800 and EM-652 are the most potent pure antiestrogens and EM-652 has the highest affinity of all antiestrogens to ER. They have no stimula...Continue Reading

Citations

Jan 12, 2008·Analytical and Bioanalytical Chemistry·Toine F H BoveeAd A C M Peijnenburg
May 24, 2012·The Breast Journal·Norasate SamarnthaiI-Tien Yeh
Dec 10, 2003·Seminars in Oncology·Bhuvaneswari Ramaswamy, Charles L Shapiro
Jul 19, 2011·The American Journal of Pathology·Yoshiya HorimotoEric W-F Lam

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