Jun 1, 1915

PURE CULTIVATION IN VIVO OF VACCINE VIRUS FREE FROM BACTERIA

The Journal of Experimental Medicine
H Noguchi

Abstract

Vaccine virus freed from all associated bacteria by means of suitable disinfecting agents can be propagated in a pure state in the testicles of rabbits and bulls. The virus cultivated in this manner is not only devoid of all bacteria, but appears capable of indefinite transfer from one animal to another. Sixty passages in rabbits of a pure strain have been made within one year. Several transfers from testicle to testicle are required to bring about accurate adaptation of the virus to the testicular parenchyma, so that continued propagation in this way can be certainly secured. During the first transfers from testicle to testicle the activity of the virus may be less than the original skin specimen from which the pure strain was derived; but as the transfers proceed the activity rises until, when the adaptation is complete, the activity of the testicular equals that of the skin strain. The multiplication of the virus within the testicle is maximum on the fourth or fifth day after inoculation; the quantity of virus remains about stationary until the eighth day, when diminution begins. At the expiration of five weeks no more virus could be detected in the testicle. The vaccinal processes in the skin, cornea, and testicle of rabbit...Continue Reading

  • References1
  • Citations15

References

  • References1
  • Citations15

Mentioned in this Paper

Structure of Calf of Leg
Cattle calf (organism)
Bos taurus
Skin Specimen
Entire Testicle
Entire Cornea
Testis
Testicular Tissue
Testicular Dysfunction
SpecimenType - Cornea

About this Paper

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