Pure germinoma occurring 11 years after total pineal mature teratoma removal: a case report and review of the literature

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Kazuki SakakuraAkira Matsumura

Abstract

Intracranial mature teratomas have good prognoses and are usually treated by total tumor resection. We report a rare case of a germinoma that occurred 11 years after total removal of a pineal mature teratoma. A 5-year-old boy presented with headache and nausea and was diagnosed with a pineal tumor and obstructive hydrocephalus on MRI. He underwent total removal of the lesion, which was pathologically diagnosed as a mature teratoma without any other germ cell tumor components. MR images after 11 years showed a newly developed pineal tumor, which was confirmed as a germinoma after neuroendoscopic biopsy. Chemoradiotherapy resulted in complete remission, without any symptoms. This case demonstrated possible late occurrence of germinoma even after total removal of a mature teratoma had been achieved. A long-term follow-up of 10 years or more should be planned for these patients.

References

Nov 17, 1998·Journal of Neurosurgery·Y SawamuraH Shirato
Aug 21, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yun-Ho LeeDong-Seok Kim
Apr 10, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Nishant GoyalBhawani Shankar Sharma
Jan 13, 2017·Acta Neuropathologica·Shintaro FukushimaUNKNOWN Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium)

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